Impact of preparation pH and temperature on amino acid stability of highly concentrated cell culture feed media

BACKGROUND The stability of amino acids (AAs) in a highly concentrated cell culture medium is affected by medium preparation and storage conditions. Variability in the concentration of medium components (including AAs) can influence cell culture performance and product quality attributes. RESULTS In...

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Veröffentlicht in:	Journal of chemical technology and biotechnology (1986) 2022-08, Vol.97 (8), p.2078-2086
Hauptverfasser:	Cui, Wanyue, Ou, Jianfa, Xu, Jianlin, Anderson, Nadine, Borys, Michael, Li, Zhengjian, Khetan, Anurag, Liu, Shijie
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid stability Amino acids Cell culture cell culture media Chemical precipitation Culture media Degradation medium preparation pH medium preparation temperature Optimization pH effects Principal components analysis Quality management Stability analysis Storage Storage conditions Storage temperature Tyrosine
Online-Zugang:	Volltext
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