139-OR: Large-Scale Sex-Stratified Additive and Recessive GWAS Identifies Novel Large-Effect Variants and Improves Polygenic Prediction for Type 2 Diabetes

Introduction: Most genome-wide association studies (GWAS) of type 2 diabetes (T2D) assume an additive mode of inheritance and equal effects in men and women. These assumptions can preclude the discovery of variants with effects that are non-additive and/or sex-specific. Focused exploration of these...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	SCHROEDER, PHILIP H., COLE, JOANNE B., LEONG, AARON, FLOREZ, JOSE C., MERCADER, JOSEP M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Biobanks Diabetes Diabetes mellitus (non-insulin dependent) Epidemiology Females Genetic diversity Genome-wide association studies Genomes Gestational diabetes Polygenic inheritance Sex
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