1336-P: FoxO1-ATGL-Sirt1-FoxO1 Feed Forward Signaling Mediates Effects on Hepatic Gene Expression and Glucose Homeostasis in LIRKO Mice

FoxO1 is a major target of insulin action and regulates expression of ATGL and its inhibitor, G0S2, in the liver (Cell Rep 15:349, 2016) . Here, we asked whether ATGL mediates effects of FoxO1 in liver-specific insulin receptor knockout (LIRKO) mice. Studies in LIRKO and IR/FoxO1 double knockout (LI...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	O-SULLIVAN, IN SUG, BHATTACHARYYA, SUMIT, LIEW, CHONG WEE, LEE, SAM M., CORDOBA-CHACON, JOSE, PERRY, RACHEL J., SHULMAN, GERALD I., UNTERMAN, TERRY
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation AKT protein Cell activation Diabetes Follistatin FOXO1 protein Gene expression Glucose Glucose metabolism Glucose tolerance Hepatocytes Homeostasis Insulin Insulin-like growth factor-binding protein 1 Lipolysis Liver Phosphorylation SIRT1 protein
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