193-LB: Differentiation of PTPN2 Knockout Pluripotent Stem Cells into Stem-Cell–Derived ß-Like Cells Leads to Increased Stimulation of Diabetogenic TCR T Cell Transductants

Type 1 diabetes (T1D) is an autoimmune disease marked by permanent loss of insulin-producing pancreatic β cells. Genome wide association studies have identified protein tyrosine non receptor type 2 (PTPN2) as a high-risk T1D gene. PTPN2 has been classically implicated in immune cell function, but is...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	MATUSCHEK, JULIA Q., RUSS, HOLGER A., TRIOLO, TAYLOR M., MICHELS, AARON W., MCDANIEL, KRISTEN, HANSEN, MARIA S., WILLIAMS, SHANE, CASTRO-GUTIERREZ, ROBERTO, SHILLEH, ALI
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Beta cells Cell death Cell differentiation Cell recognition CRISPR Diabetes Diabetes mellitus (insulin dependent) Genome-wide association studies Genomes Histocompatibility antigen HLA Immunogenicity Insulin Lymphocytes Lymphocytes T Pancreas Phenotypes Pluripotency PTPN2 protein Stem cell transplantation Stem cells T cell receptors Tyrosine
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