366-OR: 14-3-3-ζ Contributes to Effect of ß-Cell GLP1 Receptor Signaling to Alter a-Cell Proglucagon Processing

Glucagon like peptide 1 (GLP1) , a classically gut derived hormone, potentiates insulin secretion. New evidence suggests that α cells can produce GLP1 under certain conditions, which may offer a novel therapeutic modality for treating diabetes; however, the mechanisms regulating α cell GLP1 producti...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	HOLTER, MARLENA, PHUONG, DARYL, LEE, ISAAC S.H., SAIKIA, MRIDUSMITA, WEIKERT, LISA A., ANDERSON, ELIZABETH T., FU, QIN, ZHANG, SHENG, SLOOP, KYLE, CUMMINGS, BETHANY
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein Beta cells Diabetes Diabetes mellitus Gene expression Glucagon Insulin Insulin secretion Paracrine signalling Proprotein convertases Proteomes Secretion
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