186-OR: Novel Autoantibodies to Deamidated IA2 Extracellular Domain in Type 1 Diabetes

Background: Insulinoma antigen-2 (IA2) is a major self-antigen in T1D with post translational modification (PTM) of the extracellular domain (IA2ec) by deamidation eliciting T cell responses in T1D patients. Yet the autoantibodies (Abs) to these IA2ec PTM epitopes in T1D has not been studied. Method...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	JIA, XIAOFAN, MIAO, DONGMEI, ZHANG, CAIGUO, MICHELS, AARON W., YU, LIPING, WENZLAU, JANET M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoantibodies Autoantigens Children Diabetes Diabetes mellitus (insulin dependent) Epitopes Insulinoma Lymphocytes T Neuroendocrine tumors
Online-Zugang:	Volltext
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