188-OR: Metabolic Blockade of Glycolysis Can Delay the Adoptive Transfer of Type 1 Diabetes

Type 1 diabetes (T1D) is a result of insulin-secreting pancreatic β-cell destruction by autoreactive CD4 and CD8 T cells. There is no cure for T1D, but determining the role of immunometabolism in promoting autoreactive CD4+ T cell effector responses may provide a novel target in delaying T1D. System...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	CHAVEZ, MIRANDA D., MCDOWELL, RUTH, TSE, HUBERT M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Amylin Beta cells CD25 antigen CD4 antigen CD8 antigen Cell activation Cell proliferation Chemokines Deoxyglucose Diabetes Diabetes mellitus (insulin dependent) Drinking water Flow cytometry Glycolysis Hyperglycemia Inflammation Insulin Lymphocytes Lymphocytes T Metabolism Oxidative phosphorylation Peptides Phosphorylation Splenocytes β-Amyloid γ-Interferon
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