119-LB: Targeted IL-22 Improves Glucose Tolerance and Reduces Hepatic Steatosis and Hepatic Fibrosis in Murine Models of Diabetes and Liver Disease

The cytokine interleukin-22 (IL-22) is an inhibitor of cellular stress. In HFD murine models, systemic IL-22 is efficacious to restore glucose tolerance, reduce circulating triglycerides and hepatic steatosis, and improve AST:ALT ratio, but is also associated with gut and skin toxicity. As an approa...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (Supplement_1)
Hauptverfasser:	PRINS, JOHN B., SAJIIR, HARESSH, KESHVARI, SAHAR, WONG, KUAN YAU, LOCKETT, JACK, MCGUCKIN, MICHAEL, HASNAIN, SUMAIRA Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animal models Cellular stress response Collagen (type I) Diabetes Diabetes mellitus Drug development Fatty liver Fibrosis Gelatinase A Gene expression Glucose Glucose tolerance Homeostasis Insulin Interleukin 22 Liver diseases Metabolism Pancreas Phosphorylation Side effects Skin Stat3 protein Steatosis Thioacetamide Tissue inhibitor of metalloproteinase 2 Toxicity Triglycerides
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