Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4- dependent mechanism

Cardiovascular disease is the major cause of morbidity and mortality in breast cancer survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long-term vascular dysfunction caused by neoadjuvant chemotherapy (NACT) and identify novel therapeutic targets. We studied art...

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Veröffentlicht in:	The Journal of clinical investigation 2022-07, Vol.132 (13), p.1-18
Hauptverfasser:	Szczepaniak, Piotr, Siedlinski, Mateusz, Hodorowicz-Zaniewska, Diana, Nosalski, Ryszard, Mikolajczyk, Tomasz P, Dobosz, Aneta M, Dikalova, Anna, Dikalov, Sergey, Streb, Joanna, Gara, Katarzyna, Basta, Pawel, Krolczyk, Jaroslaw, Sulicka-Grodzicka, Joanna, Jozefczuk, Ewelina, Dziewulska, Anna, Saju, Blessy, Laksa, Iwona, Chen, Wei, Dormer, John, Tomaszewski, Maciej, Maffia, Pasquale, Czesnikiewicz-Guzik, Marta, Crea, Filippo, Dobrzyn, Agnieszka, Moslehi, Javid, Grodzicki, Tomasz, Harrison, David G, Guzik, Tomasz J
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteries Biomedical research Breast cancer Cancer therapies Cardiovascular disease Cardiovascular diseases Chemotherapy CYBB protein Cyclophosphamide DNA methylation Doxorubicin Endothelial cells Endothelium Experiments Hydrogen peroxide Hypertension Hypotheses Kinases Microvasculature Morbidity Mortality NAD(P)H oxidase Nitric oxide NOX4 protein Phosphorylation Post-menopause Protein kinase Proteins Radiation Smooth muscle Surgery Therapeutic targets Threonine Vasodilation Veins & arteries Womens health
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