Association between Melatonin Value and Interleukins- 1B, -18, and -33 Levels in Patients with Different Stages of Non-Alcoholic Fatty Liver Disease
[...]we aimed to assess the association between these cytokines and melatonin. [...]it can be hypothesized that the therapeutic approach that affects this process may have a significant impact. According to the Fibroscan results, three groups of participants were defined: 1- normal subjects with nor...
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| Veröffentlicht in: | Middle East journal of digestive diseases 2022-01, Vol.14 (1), p.110-117 |
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| container_title | Middle East journal of digestive diseases |
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| creator | Sohrabi, Masoudreza Ajdarkosh, Hossein Gholami, Ali Amirkalali, Bahreh Mansorian, Mohsen Reza Aten, Sima Sohrabi, Melika Nasiri-Toosi, Mohsen Zamani, Farhad Keyvani, Hossein |
| description | [...]we aimed to assess the association between these cytokines and melatonin. [...]it can be hypothesized that the therapeutic approach that affects this process may have a significant impact. According to the Fibroscan results, three groups of participants were defined: 1- normal subjects with normal serum liver enzymes levels along with normal fibrosis (< 5.8 kPa) and steatosis (< 240 dbm); 2- Mild to moderate fibrosis, defined as fibrosis between 6-9.0 kPa, steatosis less than 290 dbm, and 3- the patients with severe fibrosis and suspect of steatohepatitis (NASH) as elevated liver enzymes, severe steatosis (> 290 dbm) and fibrosis more than 9.1 kPa.16-17 Laboratory Methods All patients' blood samples were assessed in the central lab of the hospital. [...]it may be suggested that melatonin is an immune modulator that influence on inflammatory process to balance the inflammation and anti-inflammation routes and eventually protect the cell injuries in NAFLD. |
| doi_str_mv | 10.34172/mejdd.2022.263 |
| format | Article |
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[...]it can be hypothesized that the therapeutic approach that affects this process may have a significant impact. According to the Fibroscan results, three groups of participants were defined: 1- normal subjects with normal serum liver enzymes levels along with normal fibrosis (< 5.8 kPa) and steatosis (< 240 dbm); 2- Mild to moderate fibrosis, defined as fibrosis between 6-9.0 kPa, steatosis less than 290 dbm, and 3- the patients with severe fibrosis and suspect of steatohepatitis (NASH) as elevated liver enzymes, severe steatosis (> 290 dbm) and fibrosis more than 9.1 kPa.16-17 Laboratory Methods All patients' blood samples were assessed in the central lab of the hospital. 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[...]it can be hypothesized that the therapeutic approach that affects this process may have a significant impact. According to the Fibroscan results, three groups of participants were defined: 1- normal subjects with normal serum liver enzymes levels along with normal fibrosis (< 5.8 kPa) and steatosis (< 240 dbm); 2- Mild to moderate fibrosis, defined as fibrosis between 6-9.0 kPa, steatosis less than 290 dbm, and 3- the patients with severe fibrosis and suspect of steatohepatitis (NASH) as elevated liver enzymes, severe steatosis (> 290 dbm) and fibrosis more than 9.1 kPa.16-17 Laboratory Methods All patients' blood samples were assessed in the central lab of the hospital. [...]it may be suggested that melatonin is an immune modulator that influence on inflammatory process to balance the inflammation and anti-inflammation routes and eventually protect the cell injuries in NAFLD.</description><subject>Cytokines</subject><subject>Enzymes</subject><subject>Gastrointestinal surgery</subject><subject>Hepatitis</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Liver diseases</subject><subject>Melatonin</subject><subject>Metabolism</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Ultrasonic imaging</subject><issn>2008-5230</issn><issn>2008-5249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9jUtPwzAQhC0EElXpmetKXOvi2Hn5WAqFSuEhUXGtXHtNU4JdYqcV_4MfTASIueyOdr8ZQs4TNhFpUvDLd9waM-GM8wnPxREZcMZKmvFUHv_vgp2SUQhb1kvIXBbpgHxNQ_C6VrH2DtYYD4gO7rFR0bvawYtqOgTlDCxcxLbB7q12gUJyNQaalOOfExUCKtxjE6BHnvosdDHAoY4buK6txbb38BzVKwbwFh68o9NG-41vag1zFeMnVPUe2_47oAp4Rk6sagKO_uaQLOc3y9kdrR5vF7NpRXeyjBSNQZZza63KtFgrwxTTiWSFyjKGJsnSFFGUKNZc2UyzQhQStdW654yQSgzJxW_srvUfHYa42vqudX3jiuelSAopCyG-AW6AajY</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Sohrabi, Masoudreza</creator><creator>Ajdarkosh, Hossein</creator><creator>Gholami, Ali</creator><creator>Amirkalali, Bahreh</creator><creator>Mansorian, Mohsen Reza</creator><creator>Aten, Sima</creator><creator>Sohrabi, Melika</creator><creator>Nasiri-Toosi, Mohsen</creator><creator>Zamani, Farhad</creator><creator>Keyvani, Hossein</creator><general>Shiraz University of Medical Sciences</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220101</creationdate><title>Association between Melatonin Value and Interleukins- 1B, -18, and -33 Levels in Patients with Different Stages of Non-Alcoholic Fatty Liver Disease</title><author>Sohrabi, Masoudreza ; Ajdarkosh, Hossein ; Gholami, Ali ; Amirkalali, Bahreh ; Mansorian, Mohsen Reza ; Aten, Sima ; Sohrabi, Melika ; Nasiri-Toosi, Mohsen ; Zamani, Farhad ; Keyvani, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p98t-edde062fffa5c3bad0a0c1907a550ed1544ee38e3b2af5c07379ecfccdded39a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cytokines</topic><topic>Enzymes</topic><topic>Gastrointestinal surgery</topic><topic>Hepatitis</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Liver diseases</topic><topic>Melatonin</topic><topic>Metabolism</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohrabi, Masoudreza</creatorcontrib><creatorcontrib>Ajdarkosh, Hossein</creatorcontrib><creatorcontrib>Gholami, Ali</creatorcontrib><creatorcontrib>Amirkalali, Bahreh</creatorcontrib><creatorcontrib>Mansorian, Mohsen Reza</creatorcontrib><creatorcontrib>Aten, Sima</creatorcontrib><creatorcontrib>Sohrabi, Melika</creatorcontrib><creatorcontrib>Nasiri-Toosi, Mohsen</creatorcontrib><creatorcontrib>Zamani, Farhad</creatorcontrib><creatorcontrib>Keyvani, Hossein</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Middle East journal of digestive diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohrabi, Masoudreza</au><au>Ajdarkosh, Hossein</au><au>Gholami, Ali</au><au>Amirkalali, Bahreh</au><au>Mansorian, Mohsen Reza</au><au>Aten, Sima</au><au>Sohrabi, Melika</au><au>Nasiri-Toosi, Mohsen</au><au>Zamani, Farhad</au><au>Keyvani, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Melatonin Value and Interleukins- 1B, -18, and -33 Levels in Patients with Different Stages of Non-Alcoholic Fatty Liver Disease</atitle><jtitle>Middle East journal of digestive diseases</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>14</volume><issue>1</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>2008-5230</issn><eissn>2008-5249</eissn><abstract>[...]we aimed to assess the association between these cytokines and melatonin. [...]it can be hypothesized that the therapeutic approach that affects this process may have a significant impact. According to the Fibroscan results, three groups of participants were defined: 1- normal subjects with normal serum liver enzymes levels along with normal fibrosis (< 5.8 kPa) and steatosis (< 240 dbm); 2- Mild to moderate fibrosis, defined as fibrosis between 6-9.0 kPa, steatosis less than 290 dbm, and 3- the patients with severe fibrosis and suspect of steatohepatitis (NASH) as elevated liver enzymes, severe steatosis (> 290 dbm) and fibrosis more than 9.1 kPa.16-17 Laboratory Methods All patients' blood samples were assessed in the central lab of the hospital. [...]it may be suggested that melatonin is an immune modulator that influence on inflammatory process to balance the inflammation and anti-inflammation routes and eventually protect the cell injuries in NAFLD.</abstract><cop>Tehran</cop><pub>Shiraz University of Medical Sciences</pub><doi>10.34172/mejdd.2022.263</doi><tpages>8</tpages></addata></record> |
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| subjects | Cytokines Enzymes Gastrointestinal surgery Hepatitis Inflammation Insulin resistance Laboratories Liver diseases Melatonin Metabolism Pathogenesis Patients Questionnaires Regression analysis Ultrasonic imaging |
| title | Association between Melatonin Value and Interleukins- 1B, -18, and -33 Levels in Patients with Different Stages of Non-Alcoholic Fatty Liver Disease |
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