The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid

Docetaxel (DTX) has been widely used for the treatment of many types of cancer. However, DTX is poorly water-soluble and commercial DTX is formulated in non-ionic surfactant polysorbate 80 and ethanol, thereby leading to hypersensitivity and serious side effects. Herein, a polymer dual drug conjugat...

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Veröffentlicht in:	Biomaterials science 2022-06, Vol.1 (13), p.3454-3465
Hauptverfasser:	Dong, Peng, Liu, Jiaojiao, Lv, Hongshuai, Wu, Jiaan, Zhang, Naining, Wang, Si, Li, Xiaohai, Hu, Jinghua, Wang, Anny, Li, Daisy J, Wang, Dandan, Cao, Shengnan, Xie, Liangyu, Shi, Yikang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Blood circulation Conjugates Dextrans Docosahexaenoic acid Drug delivery systems Ethanol Nanoparticles Polysaccharides Self-assembly Side effects Xenotransplantation
Online-Zugang:	Volltext
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