MicroRNAs influence and longevity
Background MiRNAs play critical roles in the regulation of cellular function, life span, and the aging process. They can affect longevity positively and negatively through different aging pathways. Main text MiRNAs are a group of short non-coding RNAs that regulate gene expressions at post-transcrip...
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| Veröffentlicht in: | Egyptian Journal of Medical Human Genetics 2022-06, Vol.23 (1), p.1-16, Article 105 |
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| creator | Eshkoor, Sima Ataollahi Ghodsian, Nooshin Akhtari-Zavare, Mehrnoosh |
| description | Background
MiRNAs play critical roles in the regulation of cellular function, life span, and the aging process. They can affect longevity positively and negatively through different aging pathways.
Main text
MiRNAs are a group of short non-coding RNAs that regulate gene expressions at post-transcriptional levels. The different types of alterations in miRNAs biogenesis, mRNA expressions, and activities of miRNA-protein complexes can affect the regulation of normal post-transcriptional gene process, which may lead to aging, age-related diseases, and an earlier death. It seems that the influence of deregulation of miRNAs on senescence and age-related diseases occurring by targeting aging molecular pathways can be used for diagnosis and prognosis of them. Therefore, the expression and function of miRNAs should be studied more accurately with new applicable and validated experimental tools. However, the current review wishes to highlight simply a connection among miRNAs, senescence and some age-related diseases.
Conclusion
Despite several research indicating the key roles of miRNAs in aging and longevity, further investigations are still needed to elucidate the essential roles of miRNAs in controlling mRNA regulation, cell proliferation, death and/or protection during stress and health problems. Besides, more research on miRNAs will help to identify new targets for alternative strategies regarding effectively screen, treat, and prevent diseases as well as make slow the aging process. |
| doi_str_mv | 10.1186/s43042-022-00316-7 |
| format | Article |
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MiRNAs play critical roles in the regulation of cellular function, life span, and the aging process. They can affect longevity positively and negatively through different aging pathways.
Main text
MiRNAs are a group of short non-coding RNAs that regulate gene expressions at post-transcriptional levels. The different types of alterations in miRNAs biogenesis, mRNA expressions, and activities of miRNA-protein complexes can affect the regulation of normal post-transcriptional gene process, which may lead to aging, age-related diseases, and an earlier death. It seems that the influence of deregulation of miRNAs on senescence and age-related diseases occurring by targeting aging molecular pathways can be used for diagnosis and prognosis of them. Therefore, the expression and function of miRNAs should be studied more accurately with new applicable and validated experimental tools. However, the current review wishes to highlight simply a connection among miRNAs, senescence and some age-related diseases.
Conclusion
Despite several research indicating the key roles of miRNAs in aging and longevity, further investigations are still needed to elucidate the essential roles of miRNAs in controlling mRNA regulation, cell proliferation, death and/or protection during stress and health problems. Besides, more research on miRNAs will help to identify new targets for alternative strategies regarding effectively screen, treat, and prevent diseases as well as make slow the aging process.</description><identifier>ISSN: 2090-2441</identifier><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1186/s43042-022-00316-7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aging ; Cancer ; Cell death ; Cell proliferation ; Cognition ; Gene regulation ; Genetic aspects ; Genetic transcription ; Longevity ; Medicine ; Medicine & Public Health ; MicroRNA ; MicroRNAs ; MiRNA ; Post-transcription ; Review ; Senescence ; Stress</subject><ispartof>Egyptian Journal of Medical Human Genetics, 2022-06, Vol.23 (1), p.1-16, Article 105</ispartof><rights>The Author(s) 2022</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-88c890d9be23c08183c94dd1f3a48d51cf7bd99b642836e290c3b70d681d35ba3</citedby><cites>FETCH-LOGICAL-c496t-88c890d9be23c08183c94dd1f3a48d51cf7bd99b642836e290c3b70d681d35ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Eshkoor, Sima Ataollahi</creatorcontrib><creatorcontrib>Ghodsian, Nooshin</creatorcontrib><creatorcontrib>Akhtari-Zavare, Mehrnoosh</creatorcontrib><title>MicroRNAs influence and longevity</title><title>Egyptian Journal of Medical Human Genetics</title><addtitle>Egypt J Med Hum Genet</addtitle><description>Background
MiRNAs play critical roles in the regulation of cellular function, life span, and the aging process. They can affect longevity positively and negatively through different aging pathways.
Main text
MiRNAs are a group of short non-coding RNAs that regulate gene expressions at post-transcriptional levels. The different types of alterations in miRNAs biogenesis, mRNA expressions, and activities of miRNA-protein complexes can affect the regulation of normal post-transcriptional gene process, which may lead to aging, age-related diseases, and an earlier death. It seems that the influence of deregulation of miRNAs on senescence and age-related diseases occurring by targeting aging molecular pathways can be used for diagnosis and prognosis of them. Therefore, the expression and function of miRNAs should be studied more accurately with new applicable and validated experimental tools. However, the current review wishes to highlight simply a connection among miRNAs, senescence and some age-related diseases.
Conclusion
Despite several research indicating the key roles of miRNAs in aging and longevity, further investigations are still needed to elucidate the essential roles of miRNAs in controlling mRNA regulation, cell proliferation, death and/or protection during stress and health problems. Besides, more research on miRNAs will help to identify new targets for alternative strategies regarding effectively screen, treat, and prevent diseases as well as make slow the aging process.</description><subject>Aging</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell proliferation</subject><subject>Cognition</subject><subject>Gene regulation</subject><subject>Genetic aspects</subject><subject>Genetic transcription</subject><subject>Longevity</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MiRNA</subject><subject>Post-transcription</subject><subject>Review</subject><subject>Senescence</subject><subject>Stress</subject><issn>2090-2441</issn><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9UclKBDEQbUTB9Qc8jXjusbJ0UjkO4gYuIHoO6SQ9ZJjpaNIj-PdGW1xApAgVivdeLa-qDglMCUFxkjkDTmug5QEjopYb1Q4FBTXlnGz--G9XuzkvAETDJN-pjm6CTfH-dpYnoe-Wa99bPzG9myxjP_cvYXjdr7Y6s8z-4DPvVY_nZw-nl_X13cXV6ey6tlyJoUa0qMCp1lNmAQkyq7hzpGOGo2uI7WTrlGoFp8iEpwosayU4gcSxpjVsr7oadV00C_2UwsqkVx1N0B-FmObapCHYpdcNAArXcoue8lZyZMwRwxuJVImOYdE6HrWeUnxe-zzoRVynvoyvaWlIUQrJv1FzU0TL-nFIxq5CtnomATlSBu9a0z9QJZxfBRt734VS_0WgI6EcNufku69lCOh3t_Toli5u6Q-3tCwkNpJyAZfLp--J_2G9AUYmkls</recordid><startdate>20220627</startdate><enddate>20220627</enddate><creator>Eshkoor, Sima Ataollahi</creator><creator>Ghodsian, Nooshin</creator><creator>Akhtari-Zavare, Mehrnoosh</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20220627</creationdate><title>MicroRNAs influence and longevity</title><author>Eshkoor, Sima Ataollahi ; Ghodsian, Nooshin ; Akhtari-Zavare, Mehrnoosh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-88c890d9be23c08183c94dd1f3a48d51cf7bd99b642836e290c3b70d681d35ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aging</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Cell proliferation</topic><topic>Cognition</topic><topic>Gene regulation</topic><topic>Genetic aspects</topic><topic>Genetic transcription</topic><topic>Longevity</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MiRNA</topic><topic>Post-transcription</topic><topic>Review</topic><topic>Senescence</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eshkoor, Sima Ataollahi</creatorcontrib><creatorcontrib>Ghodsian, Nooshin</creatorcontrib><creatorcontrib>Akhtari-Zavare, Mehrnoosh</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Medical Human Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eshkoor, Sima Ataollahi</au><au>Ghodsian, Nooshin</au><au>Akhtari-Zavare, Mehrnoosh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNAs influence and longevity</atitle><jtitle>Egyptian Journal of Medical Human Genetics</jtitle><stitle>Egypt J Med Hum Genet</stitle><date>2022-06-27</date><risdate>2022</risdate><volume>23</volume><issue>1</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><artnum>105</artnum><issn>2090-2441</issn><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>Background
MiRNAs play critical roles in the regulation of cellular function, life span, and the aging process. They can affect longevity positively and negatively through different aging pathways.
Main text
MiRNAs are a group of short non-coding RNAs that regulate gene expressions at post-transcriptional levels. The different types of alterations in miRNAs biogenesis, mRNA expressions, and activities of miRNA-protein complexes can affect the regulation of normal post-transcriptional gene process, which may lead to aging, age-related diseases, and an earlier death. It seems that the influence of deregulation of miRNAs on senescence and age-related diseases occurring by targeting aging molecular pathways can be used for diagnosis and prognosis of them. Therefore, the expression and function of miRNAs should be studied more accurately with new applicable and validated experimental tools. However, the current review wishes to highlight simply a connection among miRNAs, senescence and some age-related diseases.
Conclusion
Despite several research indicating the key roles of miRNAs in aging and longevity, further investigations are still needed to elucidate the essential roles of miRNAs in controlling mRNA regulation, cell proliferation, death and/or protection during stress and health problems. Besides, more research on miRNAs will help to identify new targets for alternative strategies regarding effectively screen, treat, and prevent diseases as well as make slow the aging process.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43042-022-00316-7</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Aging Cancer Cell death Cell proliferation Cognition Gene regulation Genetic aspects Genetic transcription Longevity Medicine Medicine & Public Health MicroRNA MicroRNAs MiRNA Post-transcription Review Senescence Stress |
| title | MicroRNAs influence and longevity |
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