Examining lung microstructure using 19F MR diffusion imaging in COPD patients
Purpose To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease. Methods Dif...
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| Veröffentlicht in: | Magnetic resonance in medicine 2022-08, Vol.88 (2), p.860-870 |
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| creator | Obert, Arnd Jonathan Gutberlet, Marcel Kern, Agilo Luitger Kaireit, Till Frederik Glandorf, Julian Moher Alsady, Tawfik Wacker, Frank Hohlfeld, Jens Michael Vogel‐Claussen, Jens |
| description | Purpose
To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease.
Methods
Diffusion of fluorinated gas in the short‐time regime was measured using multiple gradient‐echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface‐to‐volume ratio was calculated using a first‐order approximation of the time‐dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized 129Xe diffusion MRI and lung function testing was analyzed.
Results
Using 19F diffusion MRI, the median surface‐to‐volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm−1 [87–144 cm−1]) compared with healthy volunteers (S/V = 164 cm−1 [160–84 cm−1], p |
| doi_str_mv | 10.1002/mrm.29237 |
| format | Article |
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To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease.
Methods
Diffusion of fluorinated gas in the short‐time regime was measured using multiple gradient‐echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface‐to‐volume ratio was calculated using a first‐order approximation of the time‐dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized 129Xe diffusion MRI and lung function testing was analyzed.
Results
Using 19F diffusion MRI, the median surface‐to‐volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm−1 [87–144 cm−1]) compared with healthy volunteers (S/V = 164 cm−1 [160–84 cm−1], p < 0.0001). No significant difference was found between measurements within 7 days for healthy (p = 0.88, median coefficient of variation = 4.3%) and diseased subjects (p = 0.58, median coefficient of variation= 6.7%). Linear correlations were found with S/V from 129Xe diffusion MRI (r = 0.85, p = 0.001) and the forced expiratory volume in 1 second (r = 0.68, p < 0.0001).
Conclusion
Examination of lung microstructure using time‐dependent diffusion measurement of inhaled 19F is feasible, repeatable, and correlates with established measurements.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.29237</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>19F ; Chronic obstructive pulmonary disease ; Coefficient of variation ; Diffusion ; Fluorination ; Lung diseases ; Lungs ; Magnetic resonance imaging ; Mathematical analysis ; Microstructure ; Obstructive lung disease ; pulmonary MRI ; Reproducibility ; Respiratory function ; surface‐to‐volume ratio ; Time dependence ; Time measurement ; Xenon 129</subject><ispartof>Magnetic resonance in medicine, 2022-08, Vol.88 (2), p.860-870</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-4157-9808 ; 0000-0001-9786-2026 ; 0000-0002-0779-0688 ; 0000-0003-1927-9876</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.29237$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.29237$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Obert, Arnd Jonathan</creatorcontrib><creatorcontrib>Gutberlet, Marcel</creatorcontrib><creatorcontrib>Kern, Agilo Luitger</creatorcontrib><creatorcontrib>Kaireit, Till Frederik</creatorcontrib><creatorcontrib>Glandorf, Julian</creatorcontrib><creatorcontrib>Moher Alsady, Tawfik</creatorcontrib><creatorcontrib>Wacker, Frank</creatorcontrib><creatorcontrib>Hohlfeld, Jens Michael</creatorcontrib><creatorcontrib>Vogel‐Claussen, Jens</creatorcontrib><title>Examining lung microstructure using 19F MR diffusion imaging in COPD patients</title><title>Magnetic resonance in medicine</title><description>Purpose
To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease.
Methods
Diffusion of fluorinated gas in the short‐time regime was measured using multiple gradient‐echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface‐to‐volume ratio was calculated using a first‐order approximation of the time‐dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized 129Xe diffusion MRI and lung function testing was analyzed.
Results
Using 19F diffusion MRI, the median surface‐to‐volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm−1 [87–144 cm−1]) compared with healthy volunteers (S/V = 164 cm−1 [160–84 cm−1], p < 0.0001). No significant difference was found between measurements within 7 days for healthy (p = 0.88, median coefficient of variation = 4.3%) and diseased subjects (p = 0.58, median coefficient of variation= 6.7%). Linear correlations were found with S/V from 129Xe diffusion MRI (r = 0.85, p = 0.001) and the forced expiratory volume in 1 second (r = 0.68, p < 0.0001).
Conclusion
Examination of lung microstructure using time‐dependent diffusion measurement of inhaled 19F is feasible, repeatable, and correlates with established measurements.</description><subject>19F</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Coefficient of variation</subject><subject>Diffusion</subject><subject>Fluorination</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Magnetic resonance imaging</subject><subject>Mathematical analysis</subject><subject>Microstructure</subject><subject>Obstructive lung disease</subject><subject>pulmonary MRI</subject><subject>Reproducibility</subject><subject>Respiratory function</subject><subject>surface‐to‐volume ratio</subject><subject>Time dependence</subject><subject>Time measurement</subject><subject>Xenon 129</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNotkMtOwzAQRS0EEqWw4A8ssU47dvyIl6i0gNSoqIK15SRO5ap5YCeC_j1uy2ZmNGd07-gi9EhgRgDovPHNjCqayis0IZzShHLFrtEEJIMkJYrdorsQ9gCglGQTlC9_TeNa1-7wYYylcaXvwuDHchi9xWM4EaJWON_iytV1XHQtdo3ZnYBr8WLz8YJ7MzjbDuEe3dTmEOzDf5-ir9Xyc_GWrDev74vnddKTLJMJB2mhLoSkJKWCcVVwW6isMqBsZWqiIi4Yr5SQ0lppiLGCpBmnombCllU6RU8X3d5336MNg953o2-jpaZCKlAUovQUzS9XP-5gj7r38W1_1AT0KSodo9LnqHS-zc9D-gfdP10f</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Obert, Arnd Jonathan</creator><creator>Gutberlet, Marcel</creator><creator>Kern, Agilo Luitger</creator><creator>Kaireit, Till Frederik</creator><creator>Glandorf, Julian</creator><creator>Moher Alsady, Tawfik</creator><creator>Wacker, Frank</creator><creator>Hohlfeld, Jens Michael</creator><creator>Vogel‐Claussen, Jens</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4157-9808</orcidid><orcidid>https://orcid.org/0000-0001-9786-2026</orcidid><orcidid>https://orcid.org/0000-0002-0779-0688</orcidid><orcidid>https://orcid.org/0000-0003-1927-9876</orcidid></search><sort><creationdate>202208</creationdate><title>Examining lung microstructure using 19F MR diffusion imaging in COPD patients</title><author>Obert, Arnd Jonathan ; Gutberlet, Marcel ; Kern, Agilo Luitger ; Kaireit, Till Frederik ; Glandorf, Julian ; Moher Alsady, Tawfik ; Wacker, Frank ; Hohlfeld, Jens Michael ; Vogel‐Claussen, Jens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1887-507e0fb6721326459b5eb98da09edaf197e0b45d9677ee7a1ae6138526f46ecd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>19F</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Coefficient of variation</topic><topic>Diffusion</topic><topic>Fluorination</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Magnetic resonance imaging</topic><topic>Mathematical analysis</topic><topic>Microstructure</topic><topic>Obstructive lung disease</topic><topic>pulmonary MRI</topic><topic>Reproducibility</topic><topic>Respiratory function</topic><topic>surface‐to‐volume ratio</topic><topic>Time dependence</topic><topic>Time measurement</topic><topic>Xenon 129</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obert, Arnd Jonathan</creatorcontrib><creatorcontrib>Gutberlet, Marcel</creatorcontrib><creatorcontrib>Kern, Agilo Luitger</creatorcontrib><creatorcontrib>Kaireit, Till Frederik</creatorcontrib><creatorcontrib>Glandorf, Julian</creatorcontrib><creatorcontrib>Moher Alsady, Tawfik</creatorcontrib><creatorcontrib>Wacker, Frank</creatorcontrib><creatorcontrib>Hohlfeld, Jens Michael</creatorcontrib><creatorcontrib>Vogel‐Claussen, Jens</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obert, Arnd Jonathan</au><au>Gutberlet, Marcel</au><au>Kern, Agilo Luitger</au><au>Kaireit, Till Frederik</au><au>Glandorf, Julian</au><au>Moher Alsady, Tawfik</au><au>Wacker, Frank</au><au>Hohlfeld, Jens Michael</au><au>Vogel‐Claussen, Jens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examining lung microstructure using 19F MR diffusion imaging in COPD patients</atitle><jtitle>Magnetic resonance in medicine</jtitle><date>2022-08</date><risdate>2022</risdate><volume>88</volume><issue>2</issue><spage>860</spage><epage>870</epage><pages>860-870</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Purpose
To examine the time‐dependent diffusion of fluorinated (19F) gas in human lungs for determination of surface‐to‐volume ratio in comparison to results from hyperpolarized 129Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease.
Methods
Diffusion of fluorinated gas in the short‐time regime was measured using multiple gradient‐echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface‐to‐volume ratio was calculated using a first‐order approximation of the time‐dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized 129Xe diffusion MRI and lung function testing was analyzed.
Results
Using 19F diffusion MRI, the median surface‐to‐volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm−1 [87–144 cm−1]) compared with healthy volunteers (S/V = 164 cm−1 [160–84 cm−1], p < 0.0001). No significant difference was found between measurements within 7 days for healthy (p = 0.88, median coefficient of variation = 4.3%) and diseased subjects (p = 0.58, median coefficient of variation= 6.7%). Linear correlations were found with S/V from 129Xe diffusion MRI (r = 0.85, p = 0.001) and the forced expiratory volume in 1 second (r = 0.68, p < 0.0001).
Conclusion
Examination of lung microstructure using time‐dependent diffusion measurement of inhaled 19F is feasible, repeatable, and correlates with established measurements.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/mrm.29237</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4157-9808</orcidid><orcidid>https://orcid.org/0000-0001-9786-2026</orcidid><orcidid>https://orcid.org/0000-0002-0779-0688</orcidid><orcidid>https://orcid.org/0000-0003-1927-9876</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 19F Chronic obstructive pulmonary disease Coefficient of variation Diffusion Fluorination Lung diseases Lungs Magnetic resonance imaging Mathematical analysis Microstructure Obstructive lung disease pulmonary MRI Reproducibility Respiratory function surface‐to‐volume ratio Time dependence Time measurement Xenon 129 |
| title | Examining lung microstructure using 19F MR diffusion imaging in COPD patients |
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