Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573
Background The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors. Objectives In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiw...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2022-06, Vol.26 (6), p.558-563 |
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| container_title | The Journal of nutrition, health & aging |
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| creator | Wu, C.-L. Nfor, O. N. Lu, W.-Y. Tantoh, D. Manli Liaw, Yung-Po |
| description | Background
The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.
Objectives
In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiwan.
Design, Participants and Setting
In this population-based cross-sectional study, we used genetic, demographic, and lifestyle data from participants recruited in Taiwan Biobank (TWB) between 2016 and 2019. We used multiple logistic regression analyses to determine the relationship between osteoporosis and variant rs2982573 genotypes (TT, TC, and CC).
Main Outcome
The primary outcome was osteoporosis.
Results
Individuals with osteoporosis (n = 515) were older than those without the disease (mean age ±SE (year); 61.324±0.361 versus 53.068 ±0.130, p |
| doi_str_mv | 10.1007/s12603-022-1796-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2678132428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2678132428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-6a42cf8dc4b9fa16692c60bd152dd4f8447b400b127d59e63d1e0b3806631bbb3</originalsourceid><addsrcrecordid>eNp1kEtPwzAQhC0EglL4AVyQJc4Bv2I7R1TKQ0IqKnC24nhDU5o42KlQ_z2uyuPEaVba2Rnth9AZJZeUEHUVKZOEZ4SxjKpCZnIPjaiSJBNK6_00M1VkShF1hI5jXBIi8kLLQ3TEc0W1lnyE3uewKofGd3HR9NjC8AnQ4Ymva4AkXVy3_XaNy87hWRzA9z742EQ8b-I7voEBQtt04LDd4GEBePo8p_jJrzatD_2iiS0OkRWa5YqfoIO6XEU4_dYxer2dvkzus8fZ3cPk-jGruGJDJkvBqlq7StiiLqmUBasksY7mzDlRayGUFYTY9J3LC5DcUSCWayIlp9ZaPkYXu9w--I81xMEs_Tp0qdIwqTTlTDCdXHTnqtI_MUBt-tC0ZdgYSswWr9nhNQmv2eI1Mt2cfyevbQvu9-KHZzKwnSGmVfcG4a_6_9QvNWaE4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2678132428</pqid></control><display><type>article</type><title>Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573</title><source>MEDLINE</source><source>SpringerLink_现刊</source><source>Alma/SFX Local Collection</source><creator>Wu, C.-L. ; Nfor, O. N. ; Lu, W.-Y. ; Tantoh, D. Manli ; Liaw, Yung-Po</creator><creatorcontrib>Wu, C.-L. ; Nfor, O. N. ; Lu, W.-Y. ; Tantoh, D. Manli ; Liaw, Yung-Po</creatorcontrib><description>Background
The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.
Objectives
In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiwan.
Design, Participants and Setting
In this population-based cross-sectional study, we used genetic, demographic, and lifestyle data from participants recruited in Taiwan Biobank (TWB) between 2016 and 2019. We used multiple logistic regression analyses to determine the relationship between osteoporosis and variant rs2982573 genotypes (TT, TC, and CC).
Main Outcome
The primary outcome was osteoporosis.
Results
Individuals with osteoporosis (n = 515) were older than those without the disease (mean age ±SE (year); 61.324±0.361 versus 53.068 ±0.130, p<0.001). There was no significant association between rs2982573 and osteoporosis (OR, 0.904; 95% CI, 0.706–1.157; p=0.422 for TC+CC when compared with the TT genotype). Coffee consumption was associated with a lower risk of osteoporosis (OR, 0.737; 95% CI, 0.592–0.918; p=0.006). The p-value for interaction between rs2982573 and coffee consumption was 0.0393. In our subgroup analyses, the adjusted ORs (95% CI) were 0.635 (0.410–0.985) in coffee drinking TC+CC individuals and 1.095 (0.809–1.482) in non-coffee drinking TC+CC individuals, respectively when compared with their TT genotype counterparts.
Conclusion
According to our study, participants in the TWB with the TC+CC genotype of ESR1 rs2982573 who consumed at least three cups of coffee per week were less likely to have osteoporosis.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-022-1796-6</identifier><identifier>PMID: 35718863</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Aging ; Coffee ; Coffee - adverse effects ; Cross-Sectional Studies ; Estrogen Receptor alpha - genetics ; Genotype ; Genotype & phenotype ; Geriatrics/Gerontology ; Health risks ; Humans ; Medicine ; Medicine & Public Health ; Neurosciences ; Nutrition ; Original Research ; Osteoporosis ; Osteoporosis - etiology ; Osteoporosis - genetics ; Polymorphism ; Polymorphism, Genetic ; Primary Care Medicine ; Quality of Life Research ; Risk Factors</subject><ispartof>The Journal of nutrition, health & aging, 2022-06, Vol.26 (6), p.558-563</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2022</rights><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-6a42cf8dc4b9fa16692c60bd152dd4f8447b400b127d59e63d1e0b3806631bbb3</citedby><cites>FETCH-LOGICAL-c372t-6a42cf8dc4b9fa16692c60bd152dd4f8447b400b127d59e63d1e0b3806631bbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-022-1796-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-022-1796-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35718863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, C.-L.</creatorcontrib><creatorcontrib>Nfor, O. N.</creatorcontrib><creatorcontrib>Lu, W.-Y.</creatorcontrib><creatorcontrib>Tantoh, D. Manli</creatorcontrib><creatorcontrib>Liaw, Yung-Po</creatorcontrib><title>Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Background
The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.
Objectives
In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiwan.
Design, Participants and Setting
In this population-based cross-sectional study, we used genetic, demographic, and lifestyle data from participants recruited in Taiwan Biobank (TWB) between 2016 and 2019. We used multiple logistic regression analyses to determine the relationship between osteoporosis and variant rs2982573 genotypes (TT, TC, and CC).
Main Outcome
The primary outcome was osteoporosis.
Results
Individuals with osteoporosis (n = 515) were older than those without the disease (mean age ±SE (year); 61.324±0.361 versus 53.068 ±0.130, p<0.001). There was no significant association between rs2982573 and osteoporosis (OR, 0.904; 95% CI, 0.706–1.157; p=0.422 for TC+CC when compared with the TT genotype). Coffee consumption was associated with a lower risk of osteoporosis (OR, 0.737; 95% CI, 0.592–0.918; p=0.006). The p-value for interaction between rs2982573 and coffee consumption was 0.0393. In our subgroup analyses, the adjusted ORs (95% CI) were 0.635 (0.410–0.985) in coffee drinking TC+CC individuals and 1.095 (0.809–1.482) in non-coffee drinking TC+CC individuals, respectively when compared with their TT genotype counterparts.
Conclusion
According to our study, participants in the TWB with the TC+CC genotype of ESR1 rs2982573 who consumed at least three cups of coffee per week were less likely to have osteoporosis.</description><subject>Aging</subject><subject>Coffee</subject><subject>Coffee - adverse effects</subject><subject>Cross-Sectional Studies</subject><subject>Estrogen Receptor alpha - genetics</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Geriatrics/Gerontology</subject><subject>Health risks</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Original Research</subject><subject>Osteoporosis</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>Risk Factors</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtPwzAQhC0EglL4AVyQJc4Bv2I7R1TKQ0IqKnC24nhDU5o42KlQ_z2uyuPEaVba2Rnth9AZJZeUEHUVKZOEZ4SxjKpCZnIPjaiSJBNK6_00M1VkShF1hI5jXBIi8kLLQ3TEc0W1lnyE3uewKofGd3HR9NjC8AnQ4Ymva4AkXVy3_XaNy87hWRzA9z742EQ8b-I7voEBQtt04LDd4GEBePo8p_jJrzatD_2iiS0OkRWa5YqfoIO6XEU4_dYxer2dvkzus8fZ3cPk-jGruGJDJkvBqlq7StiiLqmUBasksY7mzDlRayGUFYTY9J3LC5DcUSCWayIlp9ZaPkYXu9w--I81xMEs_Tp0qdIwqTTlTDCdXHTnqtI_MUBt-tC0ZdgYSswWr9nhNQmv2eI1Mt2cfyevbQvu9-KHZzKwnSGmVfcG4a_6_9QvNWaE4g</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Wu, C.-L.</creator><creator>Nfor, O. N.</creator><creator>Lu, W.-Y.</creator><creator>Tantoh, D. Manli</creator><creator>Liaw, Yung-Po</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20220601</creationdate><title>Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573</title><author>Wu, C.-L. ; Nfor, O. N. ; Lu, W.-Y. ; Tantoh, D. Manli ; Liaw, Yung-Po</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-6a42cf8dc4b9fa16692c60bd152dd4f8447b400b127d59e63d1e0b3806631bbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aging</topic><topic>Coffee</topic><topic>Coffee - adverse effects</topic><topic>Cross-Sectional Studies</topic><topic>Estrogen Receptor alpha - genetics</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Geriatrics/Gerontology</topic><topic>Health risks</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Original Research</topic><topic>Osteoporosis</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, C.-L.</creatorcontrib><creatorcontrib>Nfor, O. N.</creatorcontrib><creatorcontrib>Lu, W.-Y.</creatorcontrib><creatorcontrib>Tantoh, D. Manli</creatorcontrib><creatorcontrib>Liaw, Yung-Po</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, C.-L.</au><au>Nfor, O. N.</au><au>Lu, W.-Y.</au><au>Tantoh, D. Manli</au><au>Liaw, Yung-Po</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>26</volume><issue>6</issue><spage>558</spage><epage>563</epage><pages>558-563</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Background
The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.
Objectives
In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiwan.
Design, Participants and Setting
In this population-based cross-sectional study, we used genetic, demographic, and lifestyle data from participants recruited in Taiwan Biobank (TWB) between 2016 and 2019. We used multiple logistic regression analyses to determine the relationship between osteoporosis and variant rs2982573 genotypes (TT, TC, and CC).
Main Outcome
The primary outcome was osteoporosis.
Results
Individuals with osteoporosis (n = 515) were older than those without the disease (mean age ±SE (year); 61.324±0.361 versus 53.068 ±0.130, p<0.001). There was no significant association between rs2982573 and osteoporosis (OR, 0.904; 95% CI, 0.706–1.157; p=0.422 for TC+CC when compared with the TT genotype). Coffee consumption was associated with a lower risk of osteoporosis (OR, 0.737; 95% CI, 0.592–0.918; p=0.006). The p-value for interaction between rs2982573 and coffee consumption was 0.0393. In our subgroup analyses, the adjusted ORs (95% CI) were 0.635 (0.410–0.985) in coffee drinking TC+CC individuals and 1.095 (0.809–1.482) in non-coffee drinking TC+CC individuals, respectively when compared with their TT genotype counterparts.
Conclusion
According to our study, participants in the TWB with the TC+CC genotype of ESR1 rs2982573 who consumed at least three cups of coffee per week were less likely to have osteoporosis.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>35718863</pmid><doi>10.1007/s12603-022-1796-6</doi><tpages>6</tpages></addata></record> |
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| subjects | Aging Coffee Coffee - adverse effects Cross-Sectional Studies Estrogen Receptor alpha - genetics Genotype Genotype & phenotype Geriatrics/Gerontology Health risks Humans Medicine Medicine & Public Health Neurosciences Nutrition Original Research Osteoporosis Osteoporosis - etiology Osteoporosis - genetics Polymorphism Polymorphism, Genetic Primary Care Medicine Quality of Life Research Risk Factors |
| title | Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573 |
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