Haemostasis and Thrombosis. Spatial Organization of the Biochemical Processes at Microscale
— Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that control formation and dissolution of a fibrin clot, respectively. However, critical processes in both systems occur on specialized scaffolds but not in the liquid phase. These scaffolds are two- or three-dimensi...
Gespeichert in:
Veröffentlicht in: | Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2022, Vol.16 (2), p.107-114 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 114 |
---|---|
container_issue | 2 |
container_start_page | 107 |
container_title | Biochemistry (Moscow). Supplement series A, Membrane and cell biology |
container_volume | 16 |
creator | Panteleev, M. A. Shibeko, A. M. Nechipurenko, D. Y. Beresneva, E. A. Podoplelova, N. A. Sveshnikova, A. N. |
description | —
Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that control formation and dissolution of a fibrin clot, respectively. However, critical processes in both systems occur on specialized scaffolds but not in the liquid phase. These scaffolds are two- or three-dimensional matrices that provide special conditions for biochemical reactions. The following fundamental categories of scaffolds can be distinguished: (a) phospholipid membranes enriched with phosphatidylserine provided by a procoagulant subpopulation of activated platelets, as well as damaged endothelium; membranes of apoptotic bodies in atherosclerotic plaque; lipoproteins and plasma microvesicles; (b) complex of fibrin and extracellular matrix proteins, which is associated with platelets and is the leading scaffold for pro- and anti-fibrinolytic processes; (c) polymers containing phosphate groups, including platelet polyphosphates and neutrophil extracellular traps. For some of these scaffolds, there are speculations about their physiological significance and physical meaning, while the role of others seems mysterious or at least pathophysiological. Herein we consider existing ideas about the roles and mechanisms of the involvement of these scaffolds in haemostasis and thrombosis. |
doi_str_mv | 10.1134/S1990747822030084 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2677631086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2677631086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1614-43eba65cf1295926e3880b4ddca11651ca56c13faee9059d698cea0f0ad3fa593</originalsourceid><addsrcrecordid>eNp1ULFOwzAQtRBIlMIHsFliDvhix7FHqIAiFRWpZWKIXOfSumriYqcDfD2uimBATHf37r13p0fIJbBrAC5uZqA1K0Wp8pxxxpQ4IoM9lJVCi-OfvlSn5CzGNWOSCykH5G1ssPWxN9FFarqazlfBtwufxms625remQ2dhqXp3GcafEd9Q_sV0jvn7QpbZ9P-JXiLMWJy6Omzs8HHBOM5OWnMJuLFdx2S14f7-WicTaaPT6PbSWZBgsgEx4WRhW0g14XOJXKl2ELUtTUAsgBrCmmBNwZRs0LXUiuLhjXM1AksNB-Sq4PvNvj3Hca-Wvtd6NLJKpdlKTkwJRMLDqz9ezFgU22Da034qIBV-wyrPxkmTX7QxMTtlhh-nf8XfQHYYnOg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2677631086</pqid></control><display><type>article</type><title>Haemostasis and Thrombosis. Spatial Organization of the Biochemical Processes at Microscale</title><source>SpringerLink Journals</source><creator>Panteleev, M. A. ; Shibeko, A. M. ; Nechipurenko, D. Y. ; Beresneva, E. A. ; Podoplelova, N. A. ; Sveshnikova, A. N.</creator><creatorcontrib>Panteleev, M. A. ; Shibeko, A. M. ; Nechipurenko, D. Y. ; Beresneva, E. A. ; Podoplelova, N. A. ; Sveshnikova, A. N.</creatorcontrib><description>—
Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that control formation and dissolution of a fibrin clot, respectively. However, critical processes in both systems occur on specialized scaffolds but not in the liquid phase. These scaffolds are two- or three-dimensional matrices that provide special conditions for biochemical reactions. The following fundamental categories of scaffolds can be distinguished: (a) phospholipid membranes enriched with phosphatidylserine provided by a procoagulant subpopulation of activated platelets, as well as damaged endothelium; membranes of apoptotic bodies in atherosclerotic plaque; lipoproteins and plasma microvesicles; (b) complex of fibrin and extracellular matrix proteins, which is associated with platelets and is the leading scaffold for pro- and anti-fibrinolytic processes; (c) polymers containing phosphate groups, including platelet polyphosphates and neutrophil extracellular traps. For some of these scaffolds, there are speculations about their physiological significance and physical meaning, while the role of others seems mysterious or at least pathophysiological. Herein we consider existing ideas about the roles and mechanisms of the involvement of these scaffolds in haemostasis and thrombosis.</description><identifier>ISSN: 1990-7478</identifier><identifier>EISSN: 1990-7494</identifier><identifier>DOI: 10.1134/S1990747822030084</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Apoptosis ; Arteriosclerosis ; Atherosclerosis ; Biomedical and Life Sciences ; Blood coagulation ; Blood plasma ; Cell Biology ; Endothelium ; Extracellular matrix ; Fibrin ; Fibrinolysis ; Leukocytes (neutrophilic) ; Life Sciences ; Lipoproteins ; Liquid phases ; Membranes ; Phosphatidylserine ; Phospholipids ; Platelets ; Polyphosphates ; Reviews ; Scaffolds ; Thrombosis</subject><ispartof>Biochemistry (Moscow). Supplement series A, Membrane and cell biology, 2022, Vol.16 (2), p.107-114</ispartof><rights>Pleiades Publishing, Ltd. 2022. ISSN 1990-7478, Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2022, Vol. 16, No. 2, pp. 107–114. © Pleiades Publishing, Ltd., 2022. Russian Text © The Author(s), 2022, published in Biologicheskie Membrany, 2022, Vol. 39, No. 3, pp. 163–171.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1614-43eba65cf1295926e3880b4ddca11651ca56c13faee9059d698cea0f0ad3fa593</citedby><cites>FETCH-LOGICAL-c1614-43eba65cf1295926e3880b4ddca11651ca56c13faee9059d698cea0f0ad3fa593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1990747822030084$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1990747822030084$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Panteleev, M. A.</creatorcontrib><creatorcontrib>Shibeko, A. M.</creatorcontrib><creatorcontrib>Nechipurenko, D. Y.</creatorcontrib><creatorcontrib>Beresneva, E. A.</creatorcontrib><creatorcontrib>Podoplelova, N. A.</creatorcontrib><creatorcontrib>Sveshnikova, A. N.</creatorcontrib><title>Haemostasis and Thrombosis. Spatial Organization of the Biochemical Processes at Microscale</title><title>Biochemistry (Moscow). Supplement series A, Membrane and cell biology</title><addtitle>Biochem. Moscow Suppl. Ser. A</addtitle><description>—
Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that control formation and dissolution of a fibrin clot, respectively. However, critical processes in both systems occur on specialized scaffolds but not in the liquid phase. These scaffolds are two- or three-dimensional matrices that provide special conditions for biochemical reactions. The following fundamental categories of scaffolds can be distinguished: (a) phospholipid membranes enriched with phosphatidylserine provided by a procoagulant subpopulation of activated platelets, as well as damaged endothelium; membranes of apoptotic bodies in atherosclerotic plaque; lipoproteins and plasma microvesicles; (b) complex of fibrin and extracellular matrix proteins, which is associated with platelets and is the leading scaffold for pro- and anti-fibrinolytic processes; (c) polymers containing phosphate groups, including platelet polyphosphates and neutrophil extracellular traps. For some of these scaffolds, there are speculations about their physiological significance and physical meaning, while the role of others seems mysterious or at least pathophysiological. Herein we consider existing ideas about the roles and mechanisms of the involvement of these scaffolds in haemostasis and thrombosis.</description><subject>Apoptosis</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomedical and Life Sciences</subject><subject>Blood coagulation</subject><subject>Blood plasma</subject><subject>Cell Biology</subject><subject>Endothelium</subject><subject>Extracellular matrix</subject><subject>Fibrin</subject><subject>Fibrinolysis</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life Sciences</subject><subject>Lipoproteins</subject><subject>Liquid phases</subject><subject>Membranes</subject><subject>Phosphatidylserine</subject><subject>Phospholipids</subject><subject>Platelets</subject><subject>Polyphosphates</subject><subject>Reviews</subject><subject>Scaffolds</subject><subject>Thrombosis</subject><issn>1990-7478</issn><issn>1990-7494</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1ULFOwzAQtRBIlMIHsFliDvhix7FHqIAiFRWpZWKIXOfSumriYqcDfD2uimBATHf37r13p0fIJbBrAC5uZqA1K0Wp8pxxxpQ4IoM9lJVCi-OfvlSn5CzGNWOSCykH5G1ssPWxN9FFarqazlfBtwufxms625remQ2dhqXp3GcafEd9Q_sV0jvn7QpbZ9P-JXiLMWJy6Omzs8HHBOM5OWnMJuLFdx2S14f7-WicTaaPT6PbSWZBgsgEx4WRhW0g14XOJXKl2ELUtTUAsgBrCmmBNwZRs0LXUiuLhjXM1AksNB-Sq4PvNvj3Hca-Wvtd6NLJKpdlKTkwJRMLDqz9ezFgU22Da034qIBV-wyrPxkmTX7QxMTtlhh-nf8XfQHYYnOg</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Panteleev, M. A.</creator><creator>Shibeko, A. M.</creator><creator>Nechipurenko, D. Y.</creator><creator>Beresneva, E. A.</creator><creator>Podoplelova, N. A.</creator><creator>Sveshnikova, A. N.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>2022</creationdate><title>Haemostasis and Thrombosis. Spatial Organization of the Biochemical Processes at Microscale</title><author>Panteleev, M. A. ; Shibeko, A. M. ; Nechipurenko, D. Y. ; Beresneva, E. A. ; Podoplelova, N. A. ; Sveshnikova, A. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1614-43eba65cf1295926e3880b4ddca11651ca56c13faee9059d698cea0f0ad3fa593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apoptosis</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biomedical and Life Sciences</topic><topic>Blood coagulation</topic><topic>Blood plasma</topic><topic>Cell Biology</topic><topic>Endothelium</topic><topic>Extracellular matrix</topic><topic>Fibrin</topic><topic>Fibrinolysis</topic><topic>Leukocytes (neutrophilic)</topic><topic>Life Sciences</topic><topic>Lipoproteins</topic><topic>Liquid phases</topic><topic>Membranes</topic><topic>Phosphatidylserine</topic><topic>Phospholipids</topic><topic>Platelets</topic><topic>Polyphosphates</topic><topic>Reviews</topic><topic>Scaffolds</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panteleev, M. A.</creatorcontrib><creatorcontrib>Shibeko, A. M.</creatorcontrib><creatorcontrib>Nechipurenko, D. Y.</creatorcontrib><creatorcontrib>Beresneva, E. A.</creatorcontrib><creatorcontrib>Podoplelova, N. A.</creatorcontrib><creatorcontrib>Sveshnikova, A. N.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Biochemistry (Moscow). Supplement series A, Membrane and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panteleev, M. A.</au><au>Shibeko, A. M.</au><au>Nechipurenko, D. Y.</au><au>Beresneva, E. A.</au><au>Podoplelova, N. A.</au><au>Sveshnikova, A. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemostasis and Thrombosis. Spatial Organization of the Biochemical Processes at Microscale</atitle><jtitle>Biochemistry (Moscow). Supplement series A, Membrane and cell biology</jtitle><stitle>Biochem. Moscow Suppl. Ser. A</stitle><date>2022</date><risdate>2022</risdate><volume>16</volume><issue>2</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>1990-7478</issn><eissn>1990-7494</eissn><abstract>—
Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that control formation and dissolution of a fibrin clot, respectively. However, critical processes in both systems occur on specialized scaffolds but not in the liquid phase. These scaffolds are two- or three-dimensional matrices that provide special conditions for biochemical reactions. The following fundamental categories of scaffolds can be distinguished: (a) phospholipid membranes enriched with phosphatidylserine provided by a procoagulant subpopulation of activated platelets, as well as damaged endothelium; membranes of apoptotic bodies in atherosclerotic plaque; lipoproteins and plasma microvesicles; (b) complex of fibrin and extracellular matrix proteins, which is associated with platelets and is the leading scaffold for pro- and anti-fibrinolytic processes; (c) polymers containing phosphate groups, including platelet polyphosphates and neutrophil extracellular traps. For some of these scaffolds, there are speculations about their physiological significance and physical meaning, while the role of others seems mysterious or at least pathophysiological. Herein we consider existing ideas about the roles and mechanisms of the involvement of these scaffolds in haemostasis and thrombosis.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1990747822030084</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1990-7478 |
ispartof | Biochemistry (Moscow). Supplement series A, Membrane and cell biology, 2022, Vol.16 (2), p.107-114 |
issn | 1990-7478 1990-7494 |
language | eng |
recordid | cdi_proquest_journals_2677631086 |
source | SpringerLink Journals |
subjects | Apoptosis Arteriosclerosis Atherosclerosis Biomedical and Life Sciences Blood coagulation Blood plasma Cell Biology Endothelium Extracellular matrix Fibrin Fibrinolysis Leukocytes (neutrophilic) Life Sciences Lipoproteins Liquid phases Membranes Phosphatidylserine Phospholipids Platelets Polyphosphates Reviews Scaffolds Thrombosis |
title | Haemostasis and Thrombosis. Spatial Organization of the Biochemical Processes at Microscale |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A18%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Haemostasis%20and%20Thrombosis.%20Spatial%20Organization%20of%20the%20Biochemical%20Processes%20at%20Microscale&rft.jtitle=Biochemistry%20(Moscow).%20Supplement%20series%20A,%20Membrane%20and%20cell%20biology&rft.au=Panteleev,%20M.%20A.&rft.date=2022&rft.volume=16&rft.issue=2&rft.spage=107&rft.epage=114&rft.pages=107-114&rft.issn=1990-7478&rft.eissn=1990-7494&rft_id=info:doi/10.1134/S1990747822030084&rft_dat=%3Cproquest_cross%3E2677631086%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2677631086&rft_id=info:pmid/&rfr_iscdi=true |