Cerium oxide nanoparticles administration during machine perfusion of discarded human livers: A pilot study

The combined approach of ex situ normothermic machine perfusion (NMP) and nanotechnology represents a strategy to mitigate ischemia/reperfusion injury in liver transplantation (LT). We evaluated the uptake, distribution, and efficacy of antioxidant cerium oxide nanoparticles (nanoceria) during normo...

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Veröffentlicht in:	Liver transplantation 2022-07, Vol.28 (7), p.1173-1185
Hauptverfasser:	Del Turco, Serena, Cappello, Valentina, Tapeinos, Christos, Moscardini, Aldo, Sabatino, Laura, Battaglini, Matteo, Melandro, Fabio, Torri, Francesco, Martinelli, Caterina, Babboni, Serena, Silvestrini, Beatrice, Morganti, Riccardo, Gemmi, Mauro, De Simone, Paolo, Martins, Paulo N., Crocetti, Laura, Peris, Adriano, Campani, Daniela, Basta, Giuseppina, Ciofani, Gianni, Ghinolfi, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Biopsy Catalase Cerium Cerium oxides Cold Ischemia - methods Cytokines DNA, Mitochondrial Electron microscopy Glutathione Humans Internalization Ischemia Lipid peroxidation Liver - pathology Liver transplantation Liver Transplantation - adverse effects Liver Transplantation - methods Mass spectroscopy Mitochondrial DNA Nanoparticles Organ Preservation - methods Oxidative stress Perfusion Perfusion - methods Phenotypes Pilot Projects Reperfusion Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - prevention & control Superoxide Dismutase Telomeres
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