Development and application of an LC-MS/MS method for pharmacokinetic study of ruxolitinib in children with hemophagocytic lymphohistiocytosis

Ruxolitinib (RUX), a small molecule inhibitor of JAK1/JAK2, has been identified as the possible novel targeted agent for the treatment of hemophagocytic lymphohistiocytosis (HLH). However, due to the lack of randomized clinical trials (RCTs), it is extremely difficult to determine the effective ther...

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Veröffentlicht in:	Analytical methods 2022-06, Vol.14 (23), p.2293-233
Hauptverfasser:	Li, Zhuo, Sun, Ning, Zhang, Qing, Ma, Hong-hao, Wang, Dong, Zhao, Yun-ze, Yang, Chang-qing, Zhang, Rui, Zhao, Li-bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetonitrile Ammonium Ammonium acetate Analytical chemistry Analytical methods Calibration Case reports Children Clinical trials Creatinine Dilution Distilled water Histiocytosis Ion pairs Ionization Ions Janus kinase Janus kinase 2 Liquid chromatography Lymphocytosis Mass spectrometry Mass spectroscopy Patients Pediatrics Pharmacodynamics Pharmacokinetics Pharmacology Qualitative analysis
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