Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system
This study developed and characterized the chitosan-functionalized Fe 3 O 4 @SiO 2 nanoparticles (Fe 3 O 4 @SiO 2 @CS NP) as a drug delivery system. Fe 3 O 4 NP were first synthesized by co-precipitation method, followed by coating with SiO 2 , and functionalized with chitosan via glutaraldehyde cro...
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| Veröffentlicht in: | Chemical papers 2022-07, Vol.76 (7), p.4561-4570 |
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| creator | Nguyen, Ngoc Yen Luong, Huynh Vu Thanh Pham, Duy Toan Tran, Thi Bich Quyen Dang, Huynh Giao |
| description | This study developed and characterized the chitosan-functionalized Fe
3
O
4
@SiO
2
nanoparticles (Fe
3
O
4
@SiO
2
@CS NP) as a drug delivery system. Fe
3
O
4
NP were first synthesized by co-precipitation method, followed by coating with SiO
2
, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe
3
O
4
@SiO
2
@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe
3
O
4
@SiO
2
@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe
3
O
4
@SiO
2
@CS NP could preserve the Fe
3
O
4
magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe
3
O
4
@SiO
2
@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an adsorption capacity of 6.54 mg/g and an adsorption energy of 0.2029 kJ/mol (following the Dubinin–Radushkevich model). The curcumin adsorption process was in good agreement with the pseudo-second-order kinetics (
R
2
= 0.9975). Interestingly, in the simulated body fluid, the curcumin-loaded Fe
3
O
4
@SiO
2
@CS NP could retain the curcumin release, with no detectable drug release, in the first hour, followed by a burst release within the next hour. This confirms the contribution of CS in the system. Conclusively, the Fe
3
O
4
@SiO
2
@CS NP could be further developed to potentially become a controlled-release drug delivery system. |
| doi_str_mv | 10.1007/s11696-022-02189-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2676120880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2676120880</sourcerecordid><originalsourceid>FETCH-LOGICAL-c249t-11bfdd57f2136892a960d5c7cb1f24002e709f863ba2ae5014f30489d6bedd513</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMouK7-AU8Fz9FJ0qbNTVn8goU9uJ5D2iRrlm5bk1R2_fVGK3gTZpjL-7wwD0KXBK4JQHkTCOGCY6A0LakE3h-hGWGMYwFlcYxmwDjHnBX0FJ2FsAXIcyhghtaLNxf7oDpsx66Jru9U6z6Nzh4MW-W3L25Fs051_aB8dE1rQqbSZEMfTRedajPtx02mTes-jD9k4RCi2Z2jE6vaYC5-7xy9PtyvF094uXp8XtwtcUNzETEhtdW6KC0ljFeCKsFBF03Z1MTSHICaEoStOKsVVaYAklsGeSU0r03iCJujq6l38P37aEKU23706YMgKS85oVBVkFJ0SjW-D8EbKwfvdsofJAH5bU9O9mSyJ3_syX2C2ASFFO42xv9V_0N9AUwTcuY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2676120880</pqid></control><display><type>article</type><title>Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system</title><source>Springer Nature - Complete Springer Journals</source><creator>Nguyen, Ngoc Yen ; Luong, Huynh Vu Thanh ; Pham, Duy Toan ; Tran, Thi Bich Quyen ; Dang, Huynh Giao</creator><creatorcontrib>Nguyen, Ngoc Yen ; Luong, Huynh Vu Thanh ; Pham, Duy Toan ; Tran, Thi Bich Quyen ; Dang, Huynh Giao</creatorcontrib><description>This study developed and characterized the chitosan-functionalized Fe
3
O
4
@SiO
2
nanoparticles (Fe
3
O
4
@SiO
2
@CS NP) as a drug delivery system. Fe
3
O
4
NP were first synthesized by co-precipitation method, followed by coating with SiO
2
, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe
3
O
4
@SiO
2
@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe
3
O
4
@SiO
2
@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe
3
O
4
@SiO
2
@CS NP could preserve the Fe
3
O
4
magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe
3
O
4
@SiO
2
@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an adsorption capacity of 6.54 mg/g and an adsorption energy of 0.2029 kJ/mol (following the Dubinin–Radushkevich model). The curcumin adsorption process was in good agreement with the pseudo-second-order kinetics (
R
2
= 0.9975). Interestingly, in the simulated body fluid, the curcumin-loaded Fe
3
O
4
@SiO
2
@CS NP could retain the curcumin release, with no detectable drug release, in the first hour, followed by a burst release within the next hour. This confirms the contribution of CS in the system. Conclusively, the Fe
3
O
4
@SiO
2
@CS NP could be further developed to potentially become a controlled-release drug delivery system.</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-022-02189-x</identifier><language>eng</language><publisher>Warsaw: Versita</publisher><subject>Adsorption ; Biochemistry ; Biomedical materials ; Biotechnology ; Body fluids ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Chitosan ; Coercivity ; Crosslinking ; Drug delivery systems ; Industrial Chemistry/Chemical Engineering ; Iron oxides ; Magnetic properties ; Magnetization ; Materials Science ; Medicinal Chemistry ; Nanoparticles ; Original Paper ; Remanence ; Silicon dioxide ; Synthesis</subject><ispartof>Chemical papers, 2022-07, Vol.76 (7), p.4561-4570</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2022</rights><rights>Institute of Chemistry, Slovak Academy of Sciences 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c249t-11bfdd57f2136892a960d5c7cb1f24002e709f863ba2ae5014f30489d6bedd513</citedby><cites>FETCH-LOGICAL-c249t-11bfdd57f2136892a960d5c7cb1f24002e709f863ba2ae5014f30489d6bedd513</cites><orcidid>0000-0002-8693-3367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-022-02189-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-022-02189-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Nguyen, Ngoc Yen</creatorcontrib><creatorcontrib>Luong, Huynh Vu Thanh</creatorcontrib><creatorcontrib>Pham, Duy Toan</creatorcontrib><creatorcontrib>Tran, Thi Bich Quyen</creatorcontrib><creatorcontrib>Dang, Huynh Giao</creatorcontrib><title>Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>This study developed and characterized the chitosan-functionalized Fe
3
O
4
@SiO
2
nanoparticles (Fe
3
O
4
@SiO
2
@CS NP) as a drug delivery system. Fe
3
O
4
NP were first synthesized by co-precipitation method, followed by coating with SiO
2
, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe
3
O
4
@SiO
2
@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe
3
O
4
@SiO
2
@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe
3
O
4
@SiO
2
@CS NP could preserve the Fe
3
O
4
magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe
3
O
4
@SiO
2
@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an adsorption capacity of 6.54 mg/g and an adsorption energy of 0.2029 kJ/mol (following the Dubinin–Radushkevich model). The curcumin adsorption process was in good agreement with the pseudo-second-order kinetics (
R
2
= 0.9975). Interestingly, in the simulated body fluid, the curcumin-loaded Fe
3
O
4
@SiO
2
@CS NP could retain the curcumin release, with no detectable drug release, in the first hour, followed by a burst release within the next hour. This confirms the contribution of CS in the system. Conclusively, the Fe
3
O
4
@SiO
2
@CS NP could be further developed to potentially become a controlled-release drug delivery system.</description><subject>Adsorption</subject><subject>Biochemistry</subject><subject>Biomedical materials</subject><subject>Biotechnology</subject><subject>Body fluids</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chitosan</subject><subject>Coercivity</subject><subject>Crosslinking</subject><subject>Drug delivery systems</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Iron oxides</subject><subject>Magnetic properties</subject><subject>Magnetization</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Remanence</subject><subject>Silicon dioxide</subject><subject>Synthesis</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-AU8Fz9FJ0qbNTVn8goU9uJ5D2iRrlm5bk1R2_fVGK3gTZpjL-7wwD0KXBK4JQHkTCOGCY6A0LakE3h-hGWGMYwFlcYxmwDjHnBX0FJ2FsAXIcyhghtaLNxf7oDpsx66Jru9U6z6Nzh4MW-W3L25Fs051_aB8dE1rQqbSZEMfTRedajPtx02mTes-jD9k4RCi2Z2jE6vaYC5-7xy9PtyvF094uXp8XtwtcUNzETEhtdW6KC0ljFeCKsFBF03Z1MTSHICaEoStOKsVVaYAklsGeSU0r03iCJujq6l38P37aEKU23706YMgKS85oVBVkFJ0SjW-D8EbKwfvdsofJAH5bU9O9mSyJ3_syX2C2ASFFO42xv9V_0N9AUwTcuY</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Nguyen, Ngoc Yen</creator><creator>Luong, Huynh Vu Thanh</creator><creator>Pham, Duy Toan</creator><creator>Tran, Thi Bich Quyen</creator><creator>Dang, Huynh Giao</creator><general>Versita</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-8693-3367</orcidid></search><sort><creationdate>20220701</creationdate><title>Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system</title><author>Nguyen, Ngoc Yen ; Luong, Huynh Vu Thanh ; Pham, Duy Toan ; Tran, Thi Bich Quyen ; Dang, Huynh Giao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c249t-11bfdd57f2136892a960d5c7cb1f24002e709f863ba2ae5014f30489d6bedd513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adsorption</topic><topic>Biochemistry</topic><topic>Biomedical materials</topic><topic>Biotechnology</topic><topic>Body fluids</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Chitosan</topic><topic>Coercivity</topic><topic>Crosslinking</topic><topic>Drug delivery systems</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Iron oxides</topic><topic>Magnetic properties</topic><topic>Magnetization</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Remanence</topic><topic>Silicon dioxide</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Ngoc Yen</creatorcontrib><creatorcontrib>Luong, Huynh Vu Thanh</creatorcontrib><creatorcontrib>Pham, Duy Toan</creatorcontrib><creatorcontrib>Tran, Thi Bich Quyen</creatorcontrib><creatorcontrib>Dang, Huynh Giao</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Ngoc Yen</au><au>Luong, Huynh Vu Thanh</au><au>Pham, Duy Toan</au><au>Tran, Thi Bich Quyen</au><au>Dang, Huynh Giao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2022-07-01</date><risdate>2022</risdate><volume>76</volume><issue>7</issue><spage>4561</spage><epage>4570</epage><pages>4561-4570</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>This study developed and characterized the chitosan-functionalized Fe
3
O
4
@SiO
2
nanoparticles (Fe
3
O
4
@SiO
2
@CS NP) as a drug delivery system. Fe
3
O
4
NP were first synthesized by co-precipitation method, followed by coating with SiO
2
, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe
3
O
4
@SiO
2
@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe
3
O
4
@SiO
2
@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe
3
O
4
@SiO
2
@CS NP could preserve the Fe
3
O
4
magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe
3
O
4
@SiO
2
@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an adsorption capacity of 6.54 mg/g and an adsorption energy of 0.2029 kJ/mol (following the Dubinin–Radushkevich model). The curcumin adsorption process was in good agreement with the pseudo-second-order kinetics (
R
2
= 0.9975). Interestingly, in the simulated body fluid, the curcumin-loaded Fe
3
O
4
@SiO
2
@CS NP could retain the curcumin release, with no detectable drug release, in the first hour, followed by a burst release within the next hour. This confirms the contribution of CS in the system. Conclusively, the Fe
3
O
4
@SiO
2
@CS NP could be further developed to potentially become a controlled-release drug delivery system.</abstract><cop>Warsaw</cop><pub>Versita</pub><doi>10.1007/s11696-022-02189-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8693-3367</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0366-6352 |
| ispartof | Chemical papers, 2022-07, Vol.76 (7), p.4561-4570 |
| issn | 0366-6352 1336-9075 2585-7290 |
| language | eng |
| recordid | cdi_proquest_journals_2676120880 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Adsorption Biochemistry Biomedical materials Biotechnology Body fluids Chemistry Chemistry and Materials Science Chemistry/Food Science Chitosan Coercivity Crosslinking Drug delivery systems Industrial Chemistry/Chemical Engineering Iron oxides Magnetic properties Magnetization Materials Science Medicinal Chemistry Nanoparticles Original Paper Remanence Silicon dioxide Synthesis |
| title | Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system |
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