Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana
The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compoun...
Gespeichert in:
| Veröffentlicht in: | Bioresources 2022-08, Vol.17 (3), p.4297-4305 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4305 |
|---|---|
| container_issue | 3 |
| container_start_page | 4297 |
| container_title | Bioresources |
| container_volume | 17 |
| creator | Thanh, Bui Van Anh, Nguyen Thi Van Ha, Chu Thi Thu Thuy, Dinh Thi Thu Giang, Do Hoang Dat, Nguyen Tien |
| description | The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compound exhibited cytotoxic effects on all three cancer cell lines A549 (human lung carcinoma), MDA-MB-231 (human breast carcinoma), and DU145 (human prostate carcinoma), while berberine was the most active to DU145 cells (IC50 of 4.99 μM). This alkaloid compound also potently inhibited the production of nitric oxide with IC50 at 0.017 μM. These findings suggested that the trunks of B. wallichiana might be a good source of bioactive compounds. |
| doi_str_mv | 10.15376/biores.17.3.4297-4305 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2675902335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2675902335</sourcerecordid><originalsourceid>FETCH-LOGICAL-c331t-33ae2702778de133c72a8a7ea91d1f7cddd99d9c8761156ca3680cf1071f9b793</originalsourceid><addsrcrecordid>eNpNkE1LAzEURYMoWKt_QQKuZ8zL60wmy1r8goIbXUpIMwlNnZnUJIP239taF67uXRzuhUPINbASKhT17cqHaFMJosRyxqUoZsiqEzIBiazgwOvTf_2cXKS0YWzWILAJeZ8P2Rd-cJ3ue51D3FE9tNTscsjh2xtq1rb3RnfUhCFln0c75ERdDD3Na0tzHIePRIOjdzaubPSJfumu82bt9aAvyZnTXbJXfzklbw_3r4unYvny-LyYLwuDCLlA1JYLxoVoWguIRnDdaGG1hBacMG3bStlK04gaoKqNxrphxgET4ORKSJySm-PuNobP0aasNmGMw_5S8VpUknHEak_VR8rEkFK0Tm2j73XcKWDqV6U6qlQgFKqDSnVQiT_gCWqj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2675902335</pqid></control><display><type>article</type><title>Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Thanh, Bui Van ; Anh, Nguyen Thi Van ; Ha, Chu Thi Thu ; Thuy, Dinh Thi Thu ; Giang, Do Hoang ; Dat, Nguyen Tien</creator><creatorcontrib>Thanh, Bui Van ; Anh, Nguyen Thi Van ; Ha, Chu Thi Thu ; Thuy, Dinh Thi Thu ; Giang, Do Hoang ; Dat, Nguyen Tien</creatorcontrib><description>The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compound exhibited cytotoxic effects on all three cancer cell lines A549 (human lung carcinoma), MDA-MB-231 (human breast carcinoma), and DU145 (human prostate carcinoma), while berberine was the most active to DU145 cells (IC50 of 4.99 μM). This alkaloid compound also potently inhibited the production of nitric oxide with IC50 at 0.017 μM. These findings suggested that the trunks of B. wallichiana might be a good source of bioactive compounds.</description><identifier>ISSN: 1930-2126</identifier><identifier>EISSN: 1930-2126</identifier><identifier>DOI: 10.15376/biores.17.3.4297-4305</identifier><language>eng</language><publisher>Raleigh: North Carolina State University</publisher><subject>Alkaloids ; Berberine ; Berberis ; Bioactive compounds ; Breast cancer ; Breast carcinoma ; Cancer ; Chemical composition ; Chromatography ; Constituents ; Cytotoxicity ; Essential oils ; Experiments ; Inflammation ; Lung carcinoma ; Mass spectrometry ; Nitric oxide ; NMR ; Nuclear magnetic resonance ; Oils & fats ; Prostate carcinoma ; Safrole ; Scientific imaging ; Sensors ; Tumor cell lines</subject><ispartof>Bioresources, 2022-08, Vol.17 (3), p.4297-4305</ispartof><rights>2022. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms available at https://bioresources.cnr.ncsu.edu/about-the-journal/editorial-policies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-33ae2702778de133c72a8a7ea91d1f7cddd99d9c8761156ca3680cf1071f9b793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Thanh, Bui Van</creatorcontrib><creatorcontrib>Anh, Nguyen Thi Van</creatorcontrib><creatorcontrib>Ha, Chu Thi Thu</creatorcontrib><creatorcontrib>Thuy, Dinh Thi Thu</creatorcontrib><creatorcontrib>Giang, Do Hoang</creatorcontrib><creatorcontrib>Dat, Nguyen Tien</creatorcontrib><title>Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana</title><title>Bioresources</title><description>The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compound exhibited cytotoxic effects on all three cancer cell lines A549 (human lung carcinoma), MDA-MB-231 (human breast carcinoma), and DU145 (human prostate carcinoma), while berberine was the most active to DU145 cells (IC50 of 4.99 μM). This alkaloid compound also potently inhibited the production of nitric oxide with IC50 at 0.017 μM. These findings suggested that the trunks of B. wallichiana might be a good source of bioactive compounds.</description><subject>Alkaloids</subject><subject>Berberine</subject><subject>Berberis</subject><subject>Bioactive compounds</subject><subject>Breast cancer</subject><subject>Breast carcinoma</subject><subject>Cancer</subject><subject>Chemical composition</subject><subject>Chromatography</subject><subject>Constituents</subject><subject>Cytotoxicity</subject><subject>Essential oils</subject><subject>Experiments</subject><subject>Inflammation</subject><subject>Lung carcinoma</subject><subject>Mass spectrometry</subject><subject>Nitric oxide</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oils & fats</subject><subject>Prostate carcinoma</subject><subject>Safrole</subject><subject>Scientific imaging</subject><subject>Sensors</subject><subject>Tumor cell lines</subject><issn>1930-2126</issn><issn>1930-2126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpNkE1LAzEURYMoWKt_QQKuZ8zL60wmy1r8goIbXUpIMwlNnZnUJIP239taF67uXRzuhUPINbASKhT17cqHaFMJosRyxqUoZsiqEzIBiazgwOvTf_2cXKS0YWzWILAJeZ8P2Rd-cJ3ue51D3FE9tNTscsjh2xtq1rb3RnfUhCFln0c75ERdDD3Na0tzHIePRIOjdzaubPSJfumu82bt9aAvyZnTXbJXfzklbw_3r4unYvny-LyYLwuDCLlA1JYLxoVoWguIRnDdaGG1hBacMG3bStlK04gaoKqNxrphxgET4ORKSJySm-PuNobP0aasNmGMw_5S8VpUknHEak_VR8rEkFK0Tm2j73XcKWDqV6U6qlQgFKqDSnVQiT_gCWqj</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Thanh, Bui Van</creator><creator>Anh, Nguyen Thi Van</creator><creator>Ha, Chu Thi Thu</creator><creator>Thuy, Dinh Thi Thu</creator><creator>Giang, Do Hoang</creator><creator>Dat, Nguyen Tien</creator><general>North Carolina State University</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>M0K</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220801</creationdate><title>Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana</title><author>Thanh, Bui Van ; Anh, Nguyen Thi Van ; Ha, Chu Thi Thu ; Thuy, Dinh Thi Thu ; Giang, Do Hoang ; Dat, Nguyen Tien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-33ae2702778de133c72a8a7ea91d1f7cddd99d9c8761156ca3680cf1071f9b793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alkaloids</topic><topic>Berberine</topic><topic>Berberis</topic><topic>Bioactive compounds</topic><topic>Breast cancer</topic><topic>Breast carcinoma</topic><topic>Cancer</topic><topic>Chemical composition</topic><topic>Chromatography</topic><topic>Constituents</topic><topic>Cytotoxicity</topic><topic>Essential oils</topic><topic>Experiments</topic><topic>Inflammation</topic><topic>Lung carcinoma</topic><topic>Mass spectrometry</topic><topic>Nitric oxide</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oils & fats</topic><topic>Prostate carcinoma</topic><topic>Safrole</topic><topic>Scientific imaging</topic><topic>Sensors</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thanh, Bui Van</creatorcontrib><creatorcontrib>Anh, Nguyen Thi Van</creatorcontrib><creatorcontrib>Ha, Chu Thi Thu</creatorcontrib><creatorcontrib>Thuy, Dinh Thi Thu</creatorcontrib><creatorcontrib>Giang, Do Hoang</creatorcontrib><creatorcontrib>Dat, Nguyen Tien</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Agricultural Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Bioresources</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thanh, Bui Van</au><au>Anh, Nguyen Thi Van</au><au>Ha, Chu Thi Thu</au><au>Thuy, Dinh Thi Thu</au><au>Giang, Do Hoang</au><au>Dat, Nguyen Tien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana</atitle><jtitle>Bioresources</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>17</volume><issue>3</issue><spage>4297</spage><epage>4305</epage><pages>4297-4305</pages><issn>1930-2126</issn><eissn>1930-2126</eissn><abstract>The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compound exhibited cytotoxic effects on all three cancer cell lines A549 (human lung carcinoma), MDA-MB-231 (human breast carcinoma), and DU145 (human prostate carcinoma), while berberine was the most active to DU145 cells (IC50 of 4.99 μM). This alkaloid compound also potently inhibited the production of nitric oxide with IC50 at 0.017 μM. These findings suggested that the trunks of B. wallichiana might be a good source of bioactive compounds.</abstract><cop>Raleigh</cop><pub>North Carolina State University</pub><doi>10.15376/biores.17.3.4297-4305</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-2126 |
| ispartof | Bioresources, 2022-08, Vol.17 (3), p.4297-4305 |
| issn | 1930-2126 1930-2126 |
| language | eng |
| recordid | cdi_proquest_journals_2675902335 |
| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Alkaloids Berberine Berberis Bioactive compounds Breast cancer Breast carcinoma Cancer Chemical composition Chromatography Constituents Cytotoxicity Essential oils Experiments Inflammation Lung carcinoma Mass spectrometry Nitric oxide NMR Nuclear magnetic resonance Oils & fats Prostate carcinoma Safrole Scientific imaging Sensors Tumor cell lines |
| title | Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T23%3A00%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-inflammatory%20and%20cytotoxic%20chemical%20constituents%20from%20the%20trunks%20of%20Berberis%20wallichiana&rft.jtitle=Bioresources&rft.au=Thanh,%20Bui%20Van&rft.date=2022-08-01&rft.volume=17&rft.issue=3&rft.spage=4297&rft.epage=4305&rft.pages=4297-4305&rft.issn=1930-2126&rft.eissn=1930-2126&rft_id=info:doi/10.15376/biores.17.3.4297-4305&rft_dat=%3Cproquest_cross%3E2675902335%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2675902335&rft_id=info:pmid/&rfr_iscdi=true |