BS8 RAF ‘paradox breaker’ PLX8394 activates ERK1/2 VIA craf, with no effect on angii-induced cardiac remodelling in mice

IntroductionThe ERK1/2 cascade, a key pathway involved in cardiac remodelling, is regulated by RAF kinases. Small molecule inhibitors of RAF have been developed due to activating oncogenic mutations, however paradoxical activity has been seen in early generations of inhibitors. Therefore, ‘paradox b...

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Veröffentlicht in:	Heart (British Cardiac Society) 2022-06, Vol.108 (Suppl 1), p.A148-A148
Hauptverfasser:	Cooper, Susanna, Haines, Zoe, Meijles, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic science Clinical trials Hypertension RAF paradox remodelling
Online-Zugang:	Volltext
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