Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C
A general, safe and scalable reductive protocol, based on the in situ generation of H 2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis...
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| Veröffentlicht in: | Green chemistry : an international journal and green chemistry resource : GC 2022-06, Vol.24 (11), p.4388-4394 |
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| container_issue | 11 |
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| container_title | Green chemistry : an international journal and green chemistry resource : GC |
| container_volume | 24 |
| creator | Messa, Francesco Dilauro, Giuseppe Paparella, Andrea Nicola Silvestri, Lavinia Furlotti, Guido Iacoangeli, Tommaso Perrone, Serena Salomone, Antonio |
| description | A general, safe and scalable reductive protocol, based on the
in situ
generation of H
2
from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
The
in situ
generation of H
2
from aluminum powder and water/KOH enabled a general hydrogenation method in cholinium chloride/glycerol deep eutectic solvent under Pd/C catalysis. |
| doi_str_mv | 10.1039/d2gc00636g |
| format | Article |
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in situ
generation of H
2
from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
The
in situ
generation of H
2
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in situ
generation of H
2
from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
The
in situ
generation of H
2
from aluminum powder and water/KOH enabled a general hydrogenation method in cholinium chloride/glycerol deep eutectic solvent under Pd/C catalysis.</description><subject>Aluminum</subject><subject>Catalysis</subject><subject>Green chemistry</subject><subject>Organic compounds</subject><subject>Solvents</subject><issn>1463-9262</issn><issn>1463-9270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpFkEtLw0AQgBdRsFYv3oUFb2LsvrpJjpJqFAp60HPYx6Sm5OXuRum_N6ZST_PgmxnmQ-iSkjtKeLqwbGMIkVxujtCMCsmjlMXk-JBLdorOvN8SQmksxQw1K4AewxDAhMpg39Vf0AaPG4CAvSrhFnujaqVrwKq12A8-qKqd6o-ddd0GWhWqrvUYpq7FeodVPTRVOzS4774tuGny1S6yc3RSqtrDxV-co_fHh7fsKVq_5M_Z_ToyLKEh0pDGMUtTloA2sU64VooDM0qyZRKXVpdSUAAGfPw54QKsoLLUbKk5VVYZPkfX-7296z4H8KHYdoNrx5MFkzEXTDAuRupmTxnXee-gLHpXNcrtCkqKX53FiuXZpDMf4as97Lw5cP-6-Q-XPHL9</recordid><startdate>20220606</startdate><enddate>20220606</enddate><creator>Messa, Francesco</creator><creator>Dilauro, Giuseppe</creator><creator>Paparella, Andrea Nicola</creator><creator>Silvestri, Lavinia</creator><creator>Furlotti, Guido</creator><creator>Iacoangeli, Tommaso</creator><creator>Perrone, Serena</creator><creator>Salomone, Antonio</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7ST</scope><scope>7U6</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-4887-6805</orcidid><orcidid>https://orcid.org/0000-0003-4261-8725</orcidid><orcidid>https://orcid.org/0000-0002-3161-385X</orcidid><orcidid>https://orcid.org/0000-0002-7112-9106</orcidid><orcidid>https://orcid.org/0000-0002-1664-6151</orcidid></search><sort><creationdate>20220606</creationdate><title>Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C</title><author>Messa, Francesco ; Dilauro, Giuseppe ; Paparella, Andrea Nicola ; Silvestri, Lavinia ; Furlotti, Guido ; Iacoangeli, Tommaso ; Perrone, Serena ; Salomone, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-be97729928ebc7b83baa3e2ca62587fdbf641ee2e3039834ed416fb25b31adac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aluminum</topic><topic>Catalysis</topic><topic>Green chemistry</topic><topic>Organic compounds</topic><topic>Solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Messa, Francesco</creatorcontrib><creatorcontrib>Dilauro, Giuseppe</creatorcontrib><creatorcontrib>Paparella, Andrea Nicola</creatorcontrib><creatorcontrib>Silvestri, Lavinia</creatorcontrib><creatorcontrib>Furlotti, Guido</creatorcontrib><creatorcontrib>Iacoangeli, Tommaso</creatorcontrib><creatorcontrib>Perrone, Serena</creatorcontrib><creatorcontrib>Salomone, Antonio</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Sustainability Science Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Materials Research Database</collection><jtitle>Green chemistry : an international journal and green chemistry resource : GC</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Messa, Francesco</au><au>Dilauro, Giuseppe</au><au>Paparella, Andrea Nicola</au><au>Silvestri, Lavinia</au><au>Furlotti, Guido</au><au>Iacoangeli, Tommaso</au><au>Perrone, Serena</au><au>Salomone, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C</atitle><jtitle>Green chemistry : an international journal and green chemistry resource : GC</jtitle><date>2022-06-06</date><risdate>2022</risdate><volume>24</volume><issue>11</issue><spage>4388</spage><epage>4394</epage><pages>4388-4394</pages><issn>1463-9262</issn><eissn>1463-9270</eissn><abstract>A general, safe and scalable reductive protocol, based on the
in situ
generation of H
2
from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
The
in situ
generation of H
2
from aluminum powder and water/KOH enabled a general hydrogenation method in cholinium chloride/glycerol deep eutectic solvent under Pd/C catalysis.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d2gc00636g</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4887-6805</orcidid><orcidid>https://orcid.org/0000-0003-4261-8725</orcidid><orcidid>https://orcid.org/0000-0002-3161-385X</orcidid><orcidid>https://orcid.org/0000-0002-7112-9106</orcidid><orcidid>https://orcid.org/0000-0002-1664-6151</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1463-9262 |
| ispartof | Green chemistry : an international journal and green chemistry resource : GC, 2022-06, Vol.24 (11), p.4388-4394 |
| issn | 1463-9262 1463-9270 |
| language | eng |
| recordid | cdi_proquest_journals_2673424234 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Aluminum Catalysis Green chemistry Organic compounds Solvents |
| title | Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C |
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