N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products

Synthetic approaches to daunorubicin derivatives containing azide and propargyl fragments were developed. A series of phosphonate and bisphosphonate derivatives (including those containing P–C–P fragments) were obtained by the methods of click chemistry and by direct amidation. The obtained compound...

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Veröffentlicht in:	Medicinal chemistry research 2022-06, Vol.31 (6), p.1011-1025
Hauptverfasser:	Moiseeva, Aleksandra A., Artyushin, Oleg I., Anikina, Lada V., Klemenkova, Zinaida S., Brel, Valery K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Chemical synthesis Cytotoxicity Daunorubicin Fragments Inorganic Chemistry Medicinal Chemistry Original Research Pharmacology/Toxicology Phosphonates Phosphorylation Toxicity
Online-Zugang:	Volltext
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