Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse

BACKGROUND. Responses to conventional donor lymphocyte infusion for postallogeneic hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell-based therapy is a promising modality to treat post-HCT relapse. METHODS. We initiated this ongoing phase I trial of adopti...

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Veröffentlicht in:	The Journal of clinical investigation 2022-06, Vol.132 (11), p.1-17
Hauptverfasser:	Shapiro, Roman M, Birch, Grace C, Hu, Guangan, Cadavid, Juliana Vergara, Nikiforow, Sarah, Baginska, Joanna, Ali, Alaa K, Tarannum, Mubin, Sheffer, Michal, Abdulhamid, Yasmin Z, Rambaldi, Benedetta, Arihara, Yohei, Reynolds, Carol, Halpern, Max S, Rodig, Scott J, Cullen, Nicole, Wolff, Jacquelyn O, Pfaff, Kathleen L, Lane, Andrew A, Lindsley, R Coleman, Cutler, Corey S, Antin, Joseph H, Ho, Vincent T, Koreth, John, Gooptu, Mahasweta, Kim, Haesook T, Malmberg, Karl-Johan, Wu, Catherine J, Chen, Jianzhu, Soiffer, Robert J, Ritz, Jerome, Romee, Rizwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Chemotherapy Cytokines Cytometry Cytotoxicity Fever Graft versus host disease Immunotherapy Interleukin 2 Leukemia Lymphocytes Lymphocytes T Medical prognosis Mutation Myeloid cells Natural killer cells Pancytopenia Patients Phenotypes Remission (Medicine) Stem cell transplantation Transplantation Viremia
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