Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents

A new series of 4-(1 H -imidazol-4-yl)-2-(substituted phenyl)-1,4-dihydrobenzo[4,5]imidazo[1,2- a ]­pyrimidines have been synthesized via a one-pot reaction using PEG-400 as a green solvent in the first step and butan-1-ol in the second step. The structures of the synthesized compounds have been confirmed by spectral data, including IR, 1 H and 13 C NMR and mass spectra, and their in vitro antimicrobial and antitubercular activities have been evaluated.