Simulation Research on the Forward Problem of Magneto-Acoustic Concentration Tomography of Magnetic Nanoparticles With Magnetic Induction Based on the Relaxation Time of Magnetic Nanoparticles

Magneto-acoustic concentration tomography of magnetic nanoparticles (MNPs) with magnetic induction (MACT-MI) is an emerging method for magnetic particle imaging based on the magneto-acoustic coupling effect. However, the limitation of this method is that the concentration of magnetic nanoparticles in the human body should be regulated to prevent excessive metabolic pressure on the kidneys. Therefore, on the premise of keeping the concentration constant, the magnetic calculation method of MNPs under the relaxation mechanism is specifically studied. We deduce the optimal particle size for imaging and greatly increased the magnetic force and sound pressure of MACT-MI, which is more conducive to the acquisition of magneto-acoustic signals. In addition, rationally increasing the fluid ambient temperature and selecting the diameter of magnetic nanoparticles according to different target tissue fluids can also optimize the imaging effect. This research provides a technical basis for the application of MNPs in tumor markers and targeted drug release.