Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids

Molecular heterogeneity of hepatobiliary tumor including intertumoral and intratumoral disparity always leads to drug resistance. Here, seven hepatobiliary tumor organoids are generated to explore heterogeneity and evolution via single‐cell RNA sequencing. HCC272 with high status of epithelia‐mesenc...

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Veröffentlicht in:	Advanced science 2021-06, Vol.8 (11), p.e2003897-n/a, Article 2003897
Hauptverfasser:	Zhao, Yan, Li, Zhi‐Xuan, Zhu, Yan‐Jing, Fu, Jing, Zhao, Xiao‐Fang, Zhang, Ya‐Ni, Wang, Shan, Wu, Jian‐Min, Wang, Kai‐Ting, Wu, Rui, Sui, Cheng‐Jun, Shen, Si‐Yun, Wu, Xuan, Wang, Hong‐Yang, Gao, Dong, Chen, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Neoplasm - genetics beta Catenin - genetics Brain cancer Carbonic Anhydrase IX - genetics Cell cycle Cell Cycle Proteins - genetics Chemistry Chemistry, Multidisciplinary Cysts Digestive System Diseases - drug therapy Digestive System Diseases - genetics Digestive System Diseases - pathology Drug resistance Drug Resistance, Neoplasm - genetics Epithelial-Mesenchymal Transition - genetics Fructose-Bisphosphate Aldolase - genetics Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - pathology Gene expression Gene Expression Regulation, Neoplastic - genetics Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - genetics Growth factors hepatobiliary tumor organoid Humans Hyaluronan Receptors - genetics Intracellular Signaling Peptides and Proteins - genetics Janus Kinases - genetics Materials Science Materials Science, Multidisciplinary Metastasis Mutation Nanoscience & Nanotechnology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Organoids - drug effects Organoids - metabolism Organoids - pathology Patients Physical Sciences Physiology Principal components analysis RNA, Long Noncoding - genetics RNA-Seq Science & Technology Science & Technology - Other Topics Single-Cell Analysis STAT Transcription Factors - genetics Stem cells Technology Transcriptome - genetics tumor ecosystem tumor heterogeneity Tumors
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