ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice

Pregnancy is associated with substantial physiological changes of the heart, and disruptions in these processes can lead to peripartum cardiomyopathy (PPCM). The molecular processes that cause physiological and pathological changes in the heart during pregnancy are not well characterized. Here, we s...

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Veröffentlicht in:	The Journal of clinical investigation 2022-05, Vol.132 (10), p.1-15
Hauptverfasser:	Kouzu, Hidemichi, Tatekoshi, Yuki, Chang, Hsiang-Chun, Shapiro, Jason S, McGee, Warren A, De Jesus, Adam, Ben-Sahra, Issam, Arany, Zoltan, Leor, Jonathan, Chen, Chunlei, Blackshear, Perry J, Ardehali, Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Biomedical research Cardiac function Cardiomyocytes Cardiomyopathy Genotype & phenotype Heart failure Hypertrophy MDM2 protein Mortality mRNA p53 Protein Physiology Pregnancy Proteins Rapamycin Rodents Ubiquitin Ubiquitin-protein ligase
Online-Zugang:	Volltext
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