Hypoestins A–D: highly modified fusicoccane diterpenoids with promising Cav3.1 calcium channel inhibitory activity from Hypoestes purpurea

Hypoestins A–D (1–4), four highly modified fusicoccane diterpenoids with two unreported carbon skeletons, and hypoestins E (5) and F (6), two previously undescribed fusicoccane diterpenoids, were isolated from the aerial parts of Hypoestes purpurea. Their structures and absolute configurations were...

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Veröffentlicht in:	Organic chemistry frontiers an international journal of organic chemistry 2022-05, Vol.9 (11), p.3075-3083
Hauptverfasser:	Xing-De, Wu, Lin-Fen Ding, Wen-Yan, Li, Cheng, Bin, Tie Lei, Hao-Feng, Zhou, Qin-Shi, Zhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Calcium channels Calcium channels (voltage-gated) Carbon Circular dichroism Crystal structure Crystals Cyclopropane Dichroism Diterpenes Hypoestes Lead compounds Organic chemistry Single crystals X-ray diffraction
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