Telomere reprogramming during fetal life in low socioeconomic mothers
Background Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to fin...
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| Veröffentlicht in: | Egyptian Journal of Medical Human Genetics 2019-08, Vol.20 (1), p.1-10, Article 9 |
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| creator | Farrukh, Sadia Baig, Saeeda Hussain, Rubina Shahid, Aqsa Khan, Samahir Tariq |
| description | Background
Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to find the association between SES and telomere length of mother-newborn and genetic remodeling that occurs during fetal life.
Results
The mean telomere/single gene copy (T/S) ratio and RTL (base pairs) among 250 mother-newborn dyads were higher in cord blood of newborns (1.18 ± 0.23) (6765 ± 1350 bp) (95% confidence level) compared to maternal blood (1.13 ± 0.18) (6432 ± 1350 bp) of all SES of the Pakistani population. A positive association (
r
= 0.396,
p
|
| doi_str_mv | 10.1186/s43042-019-0007-4 |
| format | Article |
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Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to find the association between SES and telomere length of mother-newborn and genetic remodeling that occurs during fetal life.
Results
The mean telomere/single gene copy (T/S) ratio and RTL (base pairs) among 250 mother-newborn dyads were higher in cord blood of newborns (1.18 ± 0.23) (6765 ± 1350 bp) (95% confidence level) compared to maternal blood (1.13 ± 0.18) (6432 ± 1350 bp) of all SES of the Pakistani population. A positive association (
r
= 0.396,
p
< 0.05) (
F
(2,238) = 9.229,
p
< 0.05) was found between maternal and newborn telomere length by using Spearman’s correlation and regression analyses. Calculated RTL by Kruskal Wallis was found significant in low SES maternal and cord blood (5916 ± 754-6214 ± 596) compared to high SES maternal and cord blood (6818 ± 1248-7471 ± 1851).
Conclusion
Significantly longer RTL in cord blood than maternal blood was observed in the targeted Pakistani population, including the low socioeconomic group highlighting fetal telomere reprogramming. High education appears to have a strong determining factor for longer RTL.</description><identifier>ISSN: 2090-2441</identifier><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1186/s43042-019-0007-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Cord Blood ; Ethylenediaminetetraacetic acid ; Fetal programming ; Fetuses ; Infants (Newborn) ; Medicine ; Medicine & Public Health ; Neonates ; Poor women ; Risk factors ; Socioeconomic factors ; Socioeconomic status (SES) ; Telomere ; Telomeres ; Yeast</subject><ispartof>Egyptian Journal of Medical Human Genetics, 2019-08, Vol.20 (1), p.1-10, Article 9</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-14d752eb9ede5f59ad6dbdb565b0663722c2538460debf6d1fcb3d114cfc4d943</citedby><cites>FETCH-LOGICAL-c492t-14d752eb9ede5f59ad6dbdb565b0663722c2538460debf6d1fcb3d114cfc4d943</cites><orcidid>0000-0002-2424-0477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Farrukh, Sadia</creatorcontrib><creatorcontrib>Baig, Saeeda</creatorcontrib><creatorcontrib>Hussain, Rubina</creatorcontrib><creatorcontrib>Shahid, Aqsa</creatorcontrib><creatorcontrib>Khan, Samahir Tariq</creatorcontrib><title>Telomere reprogramming during fetal life in low socioeconomic mothers</title><title>Egyptian Journal of Medical Human Genetics</title><addtitle>Egypt J Med Hum Genet</addtitle><description>Background
Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to find the association between SES and telomere length of mother-newborn and genetic remodeling that occurs during fetal life.
Results
The mean telomere/single gene copy (T/S) ratio and RTL (base pairs) among 250 mother-newborn dyads were higher in cord blood of newborns (1.18 ± 0.23) (6765 ± 1350 bp) (95% confidence level) compared to maternal blood (1.13 ± 0.18) (6432 ± 1350 bp) of all SES of the Pakistani population. A positive association (
r
= 0.396,
p
< 0.05) (
F
(2,238) = 9.229,
p
< 0.05) was found between maternal and newborn telomere length by using Spearman’s correlation and regression analyses. Calculated RTL by Kruskal Wallis was found significant in low SES maternal and cord blood (5916 ± 754-6214 ± 596) compared to high SES maternal and cord blood (6818 ± 1248-7471 ± 1851).
Conclusion
Significantly longer RTL in cord blood than maternal blood was observed in the targeted Pakistani population, including the low socioeconomic group highlighting fetal telomere reprogramming. High education appears to have a strong determining factor for longer RTL.</description><subject>Analysis</subject><subject>Cord Blood</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fetal programming</subject><subject>Fetuses</subject><subject>Infants (Newborn)</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Poor women</subject><subject>Risk factors</subject><subject>Socioeconomic factors</subject><subject>Socioeconomic status (SES)</subject><subject>Telomere</subject><subject>Telomeres</subject><subject>Yeast</subject><issn>2090-2441</issn><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uctq3TAQNSWBPD8gO0PXTkeyHtEyhLQJBLJJ1kKP0a0utnUr-VLy95Hj0qaQMIsZhnMOc-Y0zQWBS0KuxLfCemC0A6I6AJAd-9IcU1DQUcbIwbv5qDkpZQsgeC_ZcXP7hEMaMWObcZfTJptxjNOm9fu8tICzGdohBmzj1A7pd1uSiwldmtIYXTum-SfmctYcBjMUPP_TT5vn77dPN3fdw-OP-5vrh84xReeOMC85RavQIw9cGS-89ZYLbkGIXlLqKO-vmACPNghPgrO9J4S54JhXrD9t7lddn8xW73IcTX7RyUT9tkh5o02eoxtQMymNkNajc4RJQIsBmQpGUuKgt6pqfV21qu1feyyz3qZ9nur5mgoJnEgJ71AbU0XjFNKcjRtjcfpaSFWfyPsFdfkBqpbH-qU0YYh1_x-BrASXUykZw18zBPQSqF4D1TVQvQSqF_N05ZTdkg3mfwd_TnoFXpyiKA</recordid><startdate>20190816</startdate><enddate>20190816</enddate><creator>Farrukh, Sadia</creator><creator>Baig, Saeeda</creator><creator>Hussain, Rubina</creator><creator>Shahid, Aqsa</creator><creator>Khan, Samahir Tariq</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2424-0477</orcidid></search><sort><creationdate>20190816</creationdate><title>Telomere reprogramming during fetal life in low socioeconomic mothers</title><author>Farrukh, Sadia ; Baig, Saeeda ; Hussain, Rubina ; Shahid, Aqsa ; Khan, Samahir Tariq</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-14d752eb9ede5f59ad6dbdb565b0663722c2538460debf6d1fcb3d114cfc4d943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Cord Blood</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Fetal programming</topic><topic>Fetuses</topic><topic>Infants (Newborn)</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Poor women</topic><topic>Risk factors</topic><topic>Socioeconomic factors</topic><topic>Socioeconomic status (SES)</topic><topic>Telomere</topic><topic>Telomeres</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrukh, Sadia</creatorcontrib><creatorcontrib>Baig, Saeeda</creatorcontrib><creatorcontrib>Hussain, Rubina</creatorcontrib><creatorcontrib>Shahid, Aqsa</creatorcontrib><creatorcontrib>Khan, Samahir Tariq</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Medical Human Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrukh, Sadia</au><au>Baig, Saeeda</au><au>Hussain, Rubina</au><au>Shahid, Aqsa</au><au>Khan, Samahir Tariq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomere reprogramming during fetal life in low socioeconomic mothers</atitle><jtitle>Egyptian Journal of Medical Human Genetics</jtitle><stitle>Egypt J Med Hum Genet</stitle><date>2019-08-16</date><risdate>2019</risdate><volume>20</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><artnum>9</artnum><issn>2090-2441</issn><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>Background
Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to find the association between SES and telomere length of mother-newborn and genetic remodeling that occurs during fetal life.
Results
The mean telomere/single gene copy (T/S) ratio and RTL (base pairs) among 250 mother-newborn dyads were higher in cord blood of newborns (1.18 ± 0.23) (6765 ± 1350 bp) (95% confidence level) compared to maternal blood (1.13 ± 0.18) (6432 ± 1350 bp) of all SES of the Pakistani population. A positive association (
r
= 0.396,
p
< 0.05) (
F
(2,238) = 9.229,
p
< 0.05) was found between maternal and newborn telomere length by using Spearman’s correlation and regression analyses. Calculated RTL by Kruskal Wallis was found significant in low SES maternal and cord blood (5916 ± 754-6214 ± 596) compared to high SES maternal and cord blood (6818 ± 1248-7471 ± 1851).
Conclusion
Significantly longer RTL in cord blood than maternal blood was observed in the targeted Pakistani population, including the low socioeconomic group highlighting fetal telomere reprogramming. High education appears to have a strong determining factor for longer RTL.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43042-019-0007-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2424-0477</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 2090-2441 1110-8630 2090-2441 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis Cord Blood Ethylenediaminetetraacetic acid Fetal programming Fetuses Infants (Newborn) Medicine Medicine & Public Health Neonates Poor women Risk factors Socioeconomic factors Socioeconomic status (SES) Telomere Telomeres Yeast |
| title | Telomere reprogramming during fetal life in low socioeconomic mothers |
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