Telomeric repeat-containing ribonucleic acid (TERRA) expression in patients with idiopathic pulmonary fibrosis
Background Idiopathic pulmonary fibrosis (IPF) represents a chronic disease with a progressive course. It is characterized by excessive lung scarring that ultimately contributes to irreversible lung function reduction. Interestingly, a type of long non-coding RNA termed as telomeric repeat-containin...
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Veröffentlicht in: | Egyptian Journal of Medical Human Genetics 2021-03, Vol.22 (1), p.20-9, Article 20 |
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creator | El-Desoky, Manal M. Hewidy, Asem A. Fouda, Ahmed M. Hisham, Fatma Azzahraa |
description | Background
Idiopathic pulmonary fibrosis (IPF) represents a chronic disease with a progressive course. It is characterized by excessive lung scarring that ultimately contributes to irreversible lung function reduction. Interestingly, a type of long non-coding RNA termed as telomeric repeat-containing RNA (TERRA) is linked to fibrosis pathophysiology, including IPF. In this study, the expression profile of TERRA was investigated in IPF patients on radiological diagnosis [unusual interstitial pattern (UIP) in high-resolution computed tomography (HRCT)] to evaluate whether it could be employed as a reliable diagnostic biomarker.
Results
TERRA expression level was significantly higher in IPF patients over healthy controls. The expression level was significantly inversely correlated with the percentage of forced vital capacity predicted (FVC% predicted). By contrast, it was significantly directly correlated with HRCT reticular extent score.
Conclusion
TERRA expression is an essential biomarker in peripheral blood of IPF patients, providing a valuable non-invasive tool for IPF diagnosis. Moreover, TERRA expression is strongly correlated with UIP in HRCT reticular extent score. |
doi_str_mv | 10.1186/s43042-021-00141-4 |
format | Article |
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Idiopathic pulmonary fibrosis (IPF) represents a chronic disease with a progressive course. It is characterized by excessive lung scarring that ultimately contributes to irreversible lung function reduction. Interestingly, a type of long non-coding RNA termed as telomeric repeat-containing RNA (TERRA) is linked to fibrosis pathophysiology, including IPF. In this study, the expression profile of TERRA was investigated in IPF patients on radiological diagnosis [unusual interstitial pattern (UIP) in high-resolution computed tomography (HRCT)] to evaluate whether it could be employed as a reliable diagnostic biomarker.
Results
TERRA expression level was significantly higher in IPF patients over healthy controls. The expression level was significantly inversely correlated with the percentage of forced vital capacity predicted (FVC% predicted). By contrast, it was significantly directly correlated with HRCT reticular extent score.
Conclusion
TERRA expression is an essential biomarker in peripheral blood of IPF patients, providing a valuable non-invasive tool for IPF diagnosis. Moreover, TERRA expression is strongly correlated with UIP in HRCT reticular extent score.</description><identifier>ISSN: 2090-2441</identifier><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1186/s43042-021-00141-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomarkers ; Care and treatment ; Chronic diseases ; Computed tomography ; Diagnosis ; Ethylenediaminetetraacetic acid ; Fibrosis ; Gene expression ; Idiopathic pulmonary fibrosis ; Long noncoding ribonucleic acid ; Lung diseases ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Peripheral blood ; Pulmonary fibrosis ; Respiratory function ; RNA ; Telomeric repeat-containing ribonucleic acid ; Unusual interstitial pattern</subject><ispartof>Egyptian Journal of Medical Human Genetics, 2021-03, Vol.22 (1), p.20-9, Article 20</ispartof><rights>The Author(s) 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-e15823a426d5e8eb3e38ea5de61bf6e27b1a20cacb138b956418a9f865d7289e3</citedby><cites>FETCH-LOGICAL-c496t-e15823a426d5e8eb3e38ea5de61bf6e27b1a20cacb138b956418a9f865d7289e3</cites><orcidid>0000-0001-8543-0592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>El-Desoky, Manal M.</creatorcontrib><creatorcontrib>Hewidy, Asem A.</creatorcontrib><creatorcontrib>Fouda, Ahmed M.</creatorcontrib><creatorcontrib>Hisham, Fatma Azzahraa</creatorcontrib><title>Telomeric repeat-containing ribonucleic acid (TERRA) expression in patients with idiopathic pulmonary fibrosis</title><title>Egyptian Journal of Medical Human Genetics</title><addtitle>Egypt J Med Hum Genet</addtitle><description>Background
Idiopathic pulmonary fibrosis (IPF) represents a chronic disease with a progressive course. It is characterized by excessive lung scarring that ultimately contributes to irreversible lung function reduction. Interestingly, a type of long non-coding RNA termed as telomeric repeat-containing RNA (TERRA) is linked to fibrosis pathophysiology, including IPF. In this study, the expression profile of TERRA was investigated in IPF patients on radiological diagnosis [unusual interstitial pattern (UIP) in high-resolution computed tomography (HRCT)] to evaluate whether it could be employed as a reliable diagnostic biomarker.
Results
TERRA expression level was significantly higher in IPF patients over healthy controls. The expression level was significantly inversely correlated with the percentage of forced vital capacity predicted (FVC% predicted). By contrast, it was significantly directly correlated with HRCT reticular extent score.
Conclusion
TERRA expression is an essential biomarker in peripheral blood of IPF patients, providing a valuable non-invasive tool for IPF diagnosis. Moreover, TERRA expression is strongly correlated with UIP in HRCT reticular extent score.</description><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Chronic diseases</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fibrosis</subject><subject>Gene expression</subject><subject>Idiopathic pulmonary fibrosis</subject><subject>Long noncoding ribonucleic acid</subject><subject>Lung diseases</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Peripheral blood</subject><subject>Pulmonary fibrosis</subject><subject>Respiratory function</subject><subject>RNA</subject><subject>Telomeric repeat-containing ribonucleic acid</subject><subject>Unusual interstitial pattern</subject><issn>2090-2441</issn><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9UU2LFDEQbUTBdfUPeGrwoode89Xp9HFYVl1YEJbxHNJJZbaGmaRNetD995bb4iqI5FDh5b2XqnpN85qzC86Nfl-VZEp0TPCOMa54p540Z4KNrBNK8ad_3J83L2rdM6Z7OaizJm3hkI9Q0LcFZnBL53NaHCZMu7bglNPJH4BencfQvt1e3d5u3rXwfS5QK-bUYmpntyCkpbbfcLlrMWAm5I408-lwzMmV-zbiVHLF-rJ5Ft2hwqtf9bz58uFqe_mpu_n88fpyc9N5NeqlA94bIZ0SOvRgYJIgDbg-gOZT1CCGiTvBvPMTl2Yae624cWM0ug-DMCPI8-Z69Q3Z7e1c8Ehd2OzQPgC57KwrC9Jottcx9sww7qVROoALY-w9VW2kEjKQ15vVay756wnqYvf5VBK1b4UemKIfh-GRtXNkiinmpTh_xOrtRg8jbXtgmlgX_2DRCXBE2jxEJPwvgVgFnvZXC8Tfw3Bmf0Zv1-gtRW8foreKRHIVVSKnHZTHjv-j-gGh-7Dr</recordid><startdate>20210319</startdate><enddate>20210319</enddate><creator>El-Desoky, Manal M.</creator><creator>Hewidy, Asem A.</creator><creator>Fouda, Ahmed M.</creator><creator>Hisham, Fatma Azzahraa</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8543-0592</orcidid></search><sort><creationdate>20210319</creationdate><title>Telomeric repeat-containing ribonucleic acid (TERRA) expression in patients with idiopathic pulmonary fibrosis</title><author>El-Desoky, Manal M. ; Hewidy, Asem A. ; Fouda, Ahmed M. ; Hisham, Fatma Azzahraa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-e15823a426d5e8eb3e38ea5de61bf6e27b1a20cacb138b956418a9f865d7289e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Care and treatment</topic><topic>Chronic diseases</topic><topic>Computed tomography</topic><topic>Diagnosis</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Fibrosis</topic><topic>Gene expression</topic><topic>Idiopathic pulmonary fibrosis</topic><topic>Long noncoding ribonucleic acid</topic><topic>Lung diseases</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Peripheral blood</topic><topic>Pulmonary fibrosis</topic><topic>Respiratory function</topic><topic>RNA</topic><topic>Telomeric repeat-containing ribonucleic acid</topic><topic>Unusual interstitial pattern</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Desoky, Manal M.</creatorcontrib><creatorcontrib>Hewidy, Asem A.</creatorcontrib><creatorcontrib>Fouda, Ahmed M.</creatorcontrib><creatorcontrib>Hisham, Fatma Azzahraa</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Medical Human Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Desoky, Manal M.</au><au>Hewidy, Asem A.</au><au>Fouda, Ahmed M.</au><au>Hisham, Fatma Azzahraa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomeric repeat-containing ribonucleic acid (TERRA) expression in patients with idiopathic pulmonary fibrosis</atitle><jtitle>Egyptian Journal of Medical Human Genetics</jtitle><stitle>Egypt J Med Hum Genet</stitle><date>2021-03-19</date><risdate>2021</risdate><volume>22</volume><issue>1</issue><spage>20</spage><epage>9</epage><pages>20-9</pages><artnum>20</artnum><issn>2090-2441</issn><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>Background
Idiopathic pulmonary fibrosis (IPF) represents a chronic disease with a progressive course. It is characterized by excessive lung scarring that ultimately contributes to irreversible lung function reduction. Interestingly, a type of long non-coding RNA termed as telomeric repeat-containing RNA (TERRA) is linked to fibrosis pathophysiology, including IPF. In this study, the expression profile of TERRA was investigated in IPF patients on radiological diagnosis [unusual interstitial pattern (UIP) in high-resolution computed tomography (HRCT)] to evaluate whether it could be employed as a reliable diagnostic biomarker.
Results
TERRA expression level was significantly higher in IPF patients over healthy controls. The expression level was significantly inversely correlated with the percentage of forced vital capacity predicted (FVC% predicted). By contrast, it was significantly directly correlated with HRCT reticular extent score.
Conclusion
TERRA expression is an essential biomarker in peripheral blood of IPF patients, providing a valuable non-invasive tool for IPF diagnosis. Moreover, TERRA expression is strongly correlated with UIP in HRCT reticular extent score.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43042-021-00141-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8543-0592</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biomarkers Care and treatment Chronic diseases Computed tomography Diagnosis Ethylenediaminetetraacetic acid Fibrosis Gene expression Idiopathic pulmonary fibrosis Long noncoding ribonucleic acid Lung diseases Medical research Medicine Medicine & Public Health Medicine, Experimental Peripheral blood Pulmonary fibrosis Respiratory function RNA Telomeric repeat-containing ribonucleic acid Unusual interstitial pattern |
title | Telomeric repeat-containing ribonucleic acid (TERRA) expression in patients with idiopathic pulmonary fibrosis |
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