Ligand-based drug design and molecular docking simulation studies of some novel anticancer compounds on MALME-3M melanoma cell line

Background Melanoma cancer causes serious health problem worldwide because of its rapid invasion to other organs and lack of satisfactory chemotherapy. The pGI 50 anticancer activity values of 70 compounds from the NCI (National Cancer Institute) on MALME-3M cell line was modeled to describe the qua...

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Veröffentlicht in:	Egyptian Journal of Medical Human Genetics 2021-01, Vol.22 (1), p.6-15, Article 6
Hauptverfasser:	Umar, Abdullahi Bello, Uzairu, Adamu, Shallangwa, Gideon Adamu, Uba, Sani
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antitumor activity Binding energy Cancer Chemotherapy Drug development Epoxy resins Force and energy Health aspects MALME-3M cell line Medicine Medicine & Public Health Melanoma Physicochemical properties Pi–pi interaction QSAR Statistical analysis Structure-activity relationships V600E-BRAF Vemurafenib
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