Synergistic anticataleptic effect of imipramine and nicotine in a rotenone-induced rat model

Rationale Some antidepressants have been previously found to produce anti-parkinsonian effect; nicotine was known to mitigate experimental neurotoxic lesions. The anticataleptic efficacy of antidepressant-nicotine co-administration is unstudied. Objectives This work aimed to evaluate anticataleptic...

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Veröffentlicht in:	Psychopharmacology 2019-11, Vol.236 (11), p.3125-3133
Hauptverfasser:	Ionov, Ilya D., Pushinskaya, Irina I., Gorev, Nicholas P., Shpilevaya, Larissa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - administration & dosage Analysis Animal experimentation Animals Antidepressants Antidepressive Agents - administration & dosage Basal ganglia Biomedical and Life Sciences Biomedicine Catalepsy Catalepsy - chemically induced Catalepsy - drug therapy Caudate-putamen Central nervous system diseases Disease Models, Animal Dopamine Dosage and administration Dose-Response Relationship, Drug Enzyme-linked immunosorbent assay Evaluation High-performance liquid chromatography Hydroxylase Imipramine Imipramine - administration & dosage Insecticides - toxicity Lesions Levodopa Liquid chromatography Male Measurement methods Methods Movement disorders Neostriatum Neurosciences Neurotoxicity Neurotoxins Nicotine Nicotine - administration & dosage Nicotinic Agonists - administration & dosage Original Investigation Pharmacology/Toxicology Psychiatry Rats Rats, Sprague-Dawley Rotenone Rotenone - toxicity Substantia nigra Substantia Nigra - drug effects Substantia Nigra - physiology Tyrosine 3-monooxygenase
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