Non‐aggregated and water soluble axially disubstituted silicon phthalocyanines: Synthesis and inhibitory effect on acetylcholinesterase enzyme

In this study, axially pyridine groups substituted silicon (IV) phthalocyanines (3PY‐7‐Si and 3PY‐8‐Si) and their water soluble derivatives 3PY‐7a‐SiQ and 3PY‐8a‐SiQ were synthesized and acetylcholinesterase inhibition properties were examined. Axially pyridine groups substituted silicon (IV) phthalocyanines (3PY‐7‐Si and 3PY‐8‐Si) and their water soluble derivatives 3PY‐7a‐SiQ and 3PY‐8a‐SiQ showed the various degrees of acetylcholinesterase inhibition activity. Their IC50 values causing 50% inhibition of the enzyme were ranged between 0.598 ± 0.068 and 0.886 ± 0.016 mM which 3PY‐7a‐SiQ was the best. These results demonstrated that the compounds might be effective agents against Alzheimer's disease. • Synthesis of axially disubstituted silicon phthalocyanines.• Synthesis of silicon phthalocyanines.• Investigation of acetylcholinesterase inhibition properties of silicon phthalocyanines.