Cysteine Cathepsins: Structure, Physiological Functions, and the Role in Carcinogenesis

— Cysteine cathepsins (Cts) also known as thiol proteinases belong to the superfamily of cysteine proteinases. Most Cts are endopeptidases; some of them exhibit exopeptidase activity. All Cts are synthesized as zymogens and activation of most of them occurs autocatalytically. Ct activity depends on...

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Veröffentlicht in:	Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2022, Vol.16 (2), p.91-103
Hauptverfasser:	Gureeva, T. A., Timoshenko, O. S., Kugaevskaya, E. V., Solovyova, N. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bioorganic Chemistry Carcinogenesis Cathepsins Cell adhesion molecules Cell migration Cell signaling Chemistry Chemistry and Materials Science Chemokines Cysteine Cytokines Cytoplasm Enzymes Extracellular matrix Growth factors Kinases Lysosomes MAP kinase Medicinal Chemistry Mesenchyme Metastases Protein kinase Proteins Proteolysis Tumors Tyrosine
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