Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells

Cytochrome P450 monooxygenase 3A4 (CYP3A4) and P-glycoprotein, encoded by multidrug resistance 1 (MDR1) gene, are responsible for the metabolism of endogenous steroids, prescribed drugs, and xenobiotics. Both genes are regulated by steroid and xenobiotic receptor (SXR), a member of nuclear hormone r...

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Veröffentlicht in:	Endocrine 2006-12, Vol.30 (3), p.261-268
Hauptverfasser:	Nagaoka, Rin, Iwasaki, Toshiharu, Rokutanda, Nana, Takeshita, Akira, Koibuchi, Yukio, Horiguchi, Jun, Shimokawa, Noriaki, Iino, Yuichi, Morishita, Yasuo, Koibuchi, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Antineoplastic Agents, Hormonal - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Breast cancer Breast Neoplasms - metabolism Cell Line, Tumor Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochrome P450 monooxygenase Dose-Response Relationship, Drug Drug Resistance, Neoplasm - physiology Endocrinology Estrogen Antagonists - metabolism Gene expression Gene Expression Regulation, Neoplastic Genes, MDR Glycoproteins Humans Ligands MDR1 protein Metabolic pathways Multidrug resistance Nuclear receptors P-Glycoprotein Pregnane X Receptor Receptor mechanisms Receptors, Steroid - metabolism Receptors, Steroid - physiology Reporter gene Retinoid X Receptors - metabolism RNA, Messenger - metabolism Small intestine Steroid hormones Steroids Tamoxifen Tamoxifen - analogs & derivatives Tamoxifen - metabolism Transcription, Genetic Transfection Xenobiotics
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