Trichosanthin down-regulated p210Bcr-Abl and enhanced imatinib-induced growth arrest in chronic myelogenous leukemia cell line K562

Trichosanthin (TCS), an active component extracted from the root tubers of traditional Chinese medical herb Tian-Hua-Fen of the Cucurbitaceae family, has long been used for medical purpose in China; there is increasing interest in developing TCS as cancer therapeutic agents. The present study was to...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2007-09, Vol.60 (4), p.581-587
Hauptverfasser:	Zhang, Kunzhong, Xu, Jianhua, Huang, Xiuwang, Wu, Lixian, Wen, Caixia, Hu, Yingying, Su, Yu, Chen, Yuanzhong, Zhang, Zhiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis Benzamides Biological and medical sciences Caspase-3 Cell growth Cell proliferation Cell Proliferation - drug effects Chemical compounds Chemotherapy Chronic myeloid leukemia Dose-Response Relationship, Drug Down-Regulation Drug Synergism Genes, abl - drug effects Hematologic and hematopoietic diseases Hsp90 protein Humans Imatinib Imatinib Mesylate K562 Cells - drug effects Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Models, Molecular Molecular modelling Myeloid leukemia NF-κB protein Pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Protein kinase C Protein-tyrosine kinase Pyrimidines - pharmacology Trichosanthin Trichosanthin - chemistry Trichosanthin - pharmacology Tubers Tyrosine
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