Transepithelial leak in Barrett's esophagus
Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscope...
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| Veröffentlicht in: | Digestive diseases and sciences 2006-12, Vol.51 (12), p.2326-2336 |
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| creator | MULLIN, J. M VALENZANO, M. C TREMBETH, S ALLEGRETTI, P. D VERRECCHIO, J. J SCHMIDT, J. D JAIN, V MEDDINGS, J. B MERCOGLIANO, G THORNTON, J. J |
| description | Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscoped, asymptomatic controls; gastroesophageal reflux disease without mucosal complications; grossly visible esophagitis; and Barrett's esophagus) consumed a sucrose solution at bedtime and collected all overnight urine. Urine volume was measured and sucrose concentration was determined by high-performance liquid chromatography. Patients with Barrett's were observed to exhibit a transepithelial leak to sucrose whose mean value was threefold greater than that seen in healthy control subjects or patients with reflux but without any mucosal defect. A parallel study of claudin tight junction proteins in endoscopy biopsy samples showed that whereas Barrett's metaplasia contains dramatically more claudin-2 and claudin-3 than is found in normal esophageal mucosa, it is markedly lower in claudins 1 and 5, indicating very different tight junction barriers. |
| doi_str_mv | 10.1007/s10620-006-9478-5 |
| format | Article |
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M ; VALENZANO, M. C ; TREMBETH, S ; ALLEGRETTI, P. D ; VERRECCHIO, J. J ; SCHMIDT, J. D ; JAIN, V ; MEDDINGS, J. B ; MERCOGLIANO, G ; THORNTON, J. J</creator><creatorcontrib>MULLIN, J. M ; VALENZANO, M. C ; TREMBETH, S ; ALLEGRETTI, P. D ; VERRECCHIO, J. J ; SCHMIDT, J. D ; JAIN, V ; MEDDINGS, J. B ; MERCOGLIANO, G ; THORNTON, J. J</creatorcontrib><description>Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscoped, asymptomatic controls; gastroesophageal reflux disease without mucosal complications; grossly visible esophagitis; and Barrett's esophagus) consumed a sucrose solution at bedtime and collected all overnight urine. Urine volume was measured and sucrose concentration was determined by high-performance liquid chromatography. Patients with Barrett's were observed to exhibit a transepithelial leak to sucrose whose mean value was threefold greater than that seen in healthy control subjects or patients with reflux but without any mucosal defect. A parallel study of claudin tight junction proteins in endoscopy biopsy samples showed that whereas Barrett's metaplasia contains dramatically more claudin-2 and claudin-3 than is found in normal esophageal mucosa, it is markedly lower in claudins 1 and 5, indicating very different tight junction barriers.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-006-9478-5</identifier><identifier>PMID: 17103306</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Amylases - blood ; Asymptomatic ; Barrett Esophagus - metabolism ; Barrett Esophagus - pathology ; Barrett Esophagus - physiopathology ; Biological and medical sciences ; Biopsy ; Case-Control Studies ; Cell Membrane Permeability - physiology ; Claudin-1 ; Claudin-3 ; Claudin-5 ; Claudins ; Epithelial Cells - metabolism ; Epithelial Cells - pathology ; Esophagus ; Esophagus - cytology ; Esophagus - metabolism ; Esophagus - physiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Medical sciences ; Membrane Proteins - metabolism ; Metaplasia - metabolism ; Metaplasia - pathology ; Metaplasia - physiopathology ; Other diseases. Semiology ; Sucrose ; Sucrose - pharmacokinetics ; Sucrose - urine ; Tight Junctions - metabolism ; Tight Junctions - pathology</subject><ispartof>Digestive diseases and sciences, 2006-12, Vol.51 (12), p.2326-2336</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2006</rights><rights>Springer Science+Business Media, Inc. 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-b4dd189a2445c0089f5a0e45b7bc88bb0ba56ab4818980eced7204a75071ab073</citedby><cites>FETCH-LOGICAL-c384t-b4dd189a2445c0089f5a0e45b7bc88bb0ba56ab4818980eced7204a75071ab073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18446012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17103306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MULLIN, J. M</creatorcontrib><creatorcontrib>VALENZANO, M. C</creatorcontrib><creatorcontrib>TREMBETH, S</creatorcontrib><creatorcontrib>ALLEGRETTI, P. D</creatorcontrib><creatorcontrib>VERRECCHIO, J. J</creatorcontrib><creatorcontrib>SCHMIDT, J. D</creatorcontrib><creatorcontrib>JAIN, V</creatorcontrib><creatorcontrib>MEDDINGS, J. B</creatorcontrib><creatorcontrib>MERCOGLIANO, G</creatorcontrib><creatorcontrib>THORNTON, J. J</creatorcontrib><title>Transepithelial leak in Barrett's esophagus</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscoped, asymptomatic controls; gastroesophageal reflux disease without mucosal complications; grossly visible esophagitis; and Barrett's esophagus) consumed a sucrose solution at bedtime and collected all overnight urine. Urine volume was measured and sucrose concentration was determined by high-performance liquid chromatography. Patients with Barrett's were observed to exhibit a transepithelial leak to sucrose whose mean value was threefold greater than that seen in healthy control subjects or patients with reflux but without any mucosal defect. A parallel study of claudin tight junction proteins in endoscopy biopsy samples showed that whereas Barrett's metaplasia contains dramatically more claudin-2 and claudin-3 than is found in normal esophageal mucosa, it is markedly lower in claudins 1 and 5, indicating very different tight junction barriers.</description><subject>Amylases - blood</subject><subject>Asymptomatic</subject><subject>Barrett Esophagus - metabolism</subject><subject>Barrett Esophagus - pathology</subject><subject>Barrett Esophagus - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Cell Membrane Permeability - physiology</subject><subject>Claudin-1</subject><subject>Claudin-3</subject><subject>Claudin-5</subject><subject>Claudins</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - pathology</subject><subject>Esophagus</subject><subject>Esophagus - cytology</subject><subject>Esophagus - metabolism</subject><subject>Esophagus - physiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Membrane Proteins - metabolism</subject><subject>Metaplasia - metabolism</subject><subject>Metaplasia - pathology</subject><subject>Metaplasia - physiopathology</subject><subject>Other diseases. 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M</au><au>VALENZANO, M. C</au><au>TREMBETH, S</au><au>ALLEGRETTI, P. D</au><au>VERRECCHIO, J. J</au><au>SCHMIDT, J. D</au><au>JAIN, V</au><au>MEDDINGS, J. B</au><au>MERCOGLIANO, G</au><au>THORNTON, J. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transepithelial leak in Barrett's esophagus</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>51</volume><issue>12</issue><spage>2326</spage><epage>2336</epage><pages>2326-2336</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscoped, asymptomatic controls; gastroesophageal reflux disease without mucosal complications; grossly visible esophagitis; and Barrett's esophagus) consumed a sucrose solution at bedtime and collected all overnight urine. Urine volume was measured and sucrose concentration was determined by high-performance liquid chromatography. Patients with Barrett's were observed to exhibit a transepithelial leak to sucrose whose mean value was threefold greater than that seen in healthy control subjects or patients with reflux but without any mucosal defect. A parallel study of claudin tight junction proteins in endoscopy biopsy samples showed that whereas Barrett's metaplasia contains dramatically more claudin-2 and claudin-3 than is found in normal esophageal mucosa, it is markedly lower in claudins 1 and 5, indicating very different tight junction barriers.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>17103306</pmid><doi>10.1007/s10620-006-9478-5</doi><tpages>11</tpages></addata></record> |
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| subjects | Amylases - blood Asymptomatic Barrett Esophagus - metabolism Barrett Esophagus - pathology Barrett Esophagus - physiopathology Biological and medical sciences Biopsy Case-Control Studies Cell Membrane Permeability - physiology Claudin-1 Claudin-3 Claudin-5 Claudins Epithelial Cells - metabolism Epithelial Cells - pathology Esophagus Esophagus - cytology Esophagus - metabolism Esophagus - physiology Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Membrane Proteins - metabolism Metaplasia - metabolism Metaplasia - pathology Metaplasia - physiopathology Other diseases. Semiology Sucrose Sucrose - pharmacokinetics Sucrose - urine Tight Junctions - metabolism Tight Junctions - pathology |
| title | Transepithelial leak in Barrett's esophagus |
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