Low intestinal glutamine level and low glutaminase activity in Crohn's disease : A rational for glutamine supplementation?

Intestinal glutamine utilization is integral to mucosal regeneration. We analyzed the systemic and intestinal glutamine status in Crohn's disease (CD) and evaluated the therapeutic effect of glutamine supplementation in an animal model of ileitis. In CD, glutamine concentrations were decreased...

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Veröffentlicht in:	Digestive diseases and sciences 2006-12, Vol.51 (12), p.2170-2179
Hauptverfasser:	SIDO, Bernd, SEEL, Cornelia, HOCHLEHNERT, Achim, BREITKREUTZ, Raoul, DRÖGE, Wulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Case-Control Studies Colon Colon - metabolism Colon - pathology Crohn Disease - diet therapy Crohn Disease - metabolism Crohn Disease - pathology Crohn's disease Dietary Supplements Disease Models, Animal Diseases of the digestive system Enteral Nutrition Female Gastroenterology. Liver. Pancreas. Abdomen Glutaminase - metabolism Glutamine - administration & dosage Glutamine - metabolism Glutamine - therapeutic use Glutathione - metabolism Humans Ileitis - chemically induced Ileitis - diet therapy Ileum - metabolism Ileum - pathology Indomethacin Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lipid Peroxidation Male Medical sciences Middle Aged Other diseases. Semiology Pharmacology. Drug treatments Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Sprague-Dawley Rectus Abdominis - metabolism Rectus Abdominis - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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