Tetraphenylethylene-DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
The supramolecular assembly of DNA conjugates, functionalized with tetraphenylethylene (TPE) sticky ends, into vesicular structures is described. The aggregation-induced emission (AIE) active TPE units allow monitoring the assembly process by fluorescence spectroscopy. The number of TPE modification...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2022-05, Vol.2 (18), p.373-377 |
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| creator | Rothenbühler, Simon Gonzalez, Adrian Iacovache, Ioan Langenegger, Simon M Zuber, Benoît Häner, Robert |
| description | The supramolecular assembly of DNA conjugates, functionalized with tetraphenylethylene (TPE) sticky ends, into vesicular structures is described. The aggregation-induced emission (AIE) active TPE units allow monitoring the assembly process by fluorescence spectroscopy. The number of TPE modifications in the overhangs of the conjugates influences the supramolecular assembly behavior. A minimum of two TPE residues on each end are required to ensure a well-defined assembly process. The design of the presented DNA-based nanostructures offers tailored functionalization with applications in DNA nanotechnology.
The supramolecular assembly of tetraphenylethylene (TPE)-DNA conjugates is presented. The length of the TPE sticky ends exerts a pronounced effect on the formation of aggregation-induced emission (AIE)-active vesicles. |
| doi_str_mv | 10.1039/d2ob00357k |
| format | Article |
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The supramolecular assembly of tetraphenylethylene (TPE)-DNA conjugates is presented. 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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Assembly Base Sequence Chemistry Conjugates Deoxyribonucleic acid DNA Fluorescence Fluorescence spectroscopy Nanotechnology Nucleotide sequence Stilbenes - chemistry |
| title | Tetraphenylethylene-DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles |
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