Comments on: Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus
Reply from the Author The first two third of the correspondence mentioned facts on the etiology of diabetes that are already described in details in the introduction and discussion parts of the article published by Yousuf et al.1 In human genetic association studies, cases group is selected based on...
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| Veröffentlicht in: | Saudi medical journal 2022-04, Vol.43 (4), p.431-432 |
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| creator | Alsaeed, Abdulghani Yousuf, Amjad M |
| description | Reply from the Author The first two third of the correspondence mentioned facts on the etiology of diabetes that are already described in details in the introduction and discussion parts of the article published by Yousuf et al.1 In human genetic association studies, cases group is selected based on the presence of the studied phenotype (in this case diabetes) and the control group is selected based on the absence of the studied phenotype (absence of diabetes=normal blood sugar based on fasting blood glucose and level of HbA1c). Among the environmental factors are sugar intake, tobacco use, level of physical activity, stress, sleep deprivation, obesity and many others. In human genetic association studies, it is impossible to control for all such factors. [...]the BMI point raised in the correspondence is also not valid. |
| doi_str_mv | 10.15537/smj.2022.43.4.20220218 |
| format | Article |
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Among the environmental factors are sugar intake, tobacco use, level of physical activity, stress, sleep deprivation, obesity and many others. In human genetic association studies, it is impossible to control for all such factors. 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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Body fat Body Mass Index Diabetes Diabetes Mellitus, Type 2 - genetics Genetic Predisposition to Disease Genotype Humans Mutation Obesity Obesity - complications Obesity - genetics Polymorphism, Single Nucleotide |
| title | Comments on: Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus |
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