Some INSTIs inhibit the beiging capacity of white adipose tissue in vivo and in vitro, resulting in dysfunctional hypertrophic adipose tissue

Some HIV-infected patients receiving an integrase strand transfer inhibitor (INSTI), especially dolutegravir (DTG) and bictegravir (BIC), display an accumulation of adipose tissue (AT) leading to weight gain which is associated with increased cardiometabolic risk. Adipose tissue (AT) plays an essent...

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Veröffentlicht in:	Antiviral therapy 2021-12, Vol.26, p.1
Hauptverfasser:	Ayissi, K Ngono, Gorwood, J, Bourgeois, C, Lambotte, O, Le Pelletier, L, Atlan, M, Motterlini, R, esti, R, Fève, B, Capeau, J, Béréziat, V, Lagathu, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Body fat Energy balance Energy expenditure Energy storage Fatty acids HIV Homeostasis Human immunodeficiency virus Hypertrophy Integrase Leptin Mitochondria Oxidative stress Phenotypes Stromal cells
Online-Zugang:	Volltext
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