Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis

Mycobacterium tuberculosis DNA gyrase manipulates the DNA topology using controlled breakage and religation of DNA driven by ATP hydrolysis. DNA gyrase has been validated as the enzyme target of fluoroquinolones (FQs), second-line antibiotics used for the treatment of multidrug-resistant tuberculosi...

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Veröffentlicht in:	Journal of chemical information and modeling 2022-04, Vol.62 (7), p.1680-1690
Hauptverfasser:	Pakamwong, Bongkochawan, Thongdee, Paptawan, Kamsri, Bundit, Phusi, Naruedon, Kamsri, Pharit, Punkvang, Auradee, Ketrat, Sombat, Saparpakorn, Patchreenart, Hannongbua, Supa, Ariyachaokun, Kanchiyaphat, Suttisintong, Khomson, Sureram, Sanya, Kittakoop, Prasat, Hongmanee, Poonpilas, Santanirand, Pitak, Spencer, James, Mulholland, Adrian J, Pungpo, Pornpan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Adenosine Triphosphate Antibiotics Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Binding sites Bioassays Computational Chemistry DNA Gyrase - chemistry Humans Hydrogen bonds Hydrophobicity Inhibitors Microbial Sensitivity Tests Molecular dynamics Mutation Mycobacterium tuberculosis Optimization Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - pharmacology Topoisomerase II Inhibitors - therapeutic use Topology Tuberculosis Tuberculosis - drug therapy
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