Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients
Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient. Study Design: Cross-sectional study. Place and Duration of Study: Hematology...
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| Veröffentlicht in: | Pakistan Armed Forces medical journal 2022-02, Vol.72 (1), p.159-63 |
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| creator | Irshad, Zareen Jaffar, Nazish Zehra, Talat Zeeshan, Faiza Tashfeen, Sunila Sheikh, Asma |
| description | Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient.
Study Design: Cross-sectional study.
Place and Duration of Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Karachi Pakistan, from Aug 2016 to Feb 2017.
Methodology: A total of 135, serologically proven positive dengue-infected IgM cases, based on enzyme-linked immunesorbent assay, were included in the study. Prothrombin time, activated partial thromboplastin time, and fibrin degradation products levels were measured on STA Compact Max® (STAGO) and SysmexCA-1500. Clinical Outcomes of the patient were noted.
Results: At the time of admission, elevated prothrombin time was observed in 8(5.6%) cases and remained high at the time of discharge (p-value 0.008). Elevated activated partial thromboplastin time was observed in 57 (42.2%) cases at admission whereas, at discharge, it was observed in 56 (41.5%) cases. Increased level (>5) of fibrin degradation products was seen in 30 (22.2%) cases while at the time of discharge increased level of fibrin degradation products was observed in 25 (18.5%) cases (pvalue 0.007). Out of 135 patients, mortality was observed in two cases and the remaining 133 (98.52%) survived and were discharged.
Conclusion: In conclusion, prothrombin time, activated partial thromboplastin time, and fibrin degradation products can be labeled as early predictors of disease severity and their derangements are associated with clinical outcome in dengue infection. |
| doi_str_mv | 10.51253/pafmj.v72i1.4255 |
| format | Article |
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Study Design: Cross-sectional study.
Place and Duration of Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Karachi Pakistan, from Aug 2016 to Feb 2017.
Methodology: A total of 135, serologically proven positive dengue-infected IgM cases, based on enzyme-linked immunesorbent assay, were included in the study. Prothrombin time, activated partial thromboplastin time, and fibrin degradation products levels were measured on STA Compact Max® (STAGO) and SysmexCA-1500. Clinical Outcomes of the patient were noted.
Results: At the time of admission, elevated prothrombin time was observed in 8(5.6%) cases and remained high at the time of discharge (p-value 0.008). Elevated activated partial thromboplastin time was observed in 57 (42.2%) cases at admission whereas, at discharge, it was observed in 56 (41.5%) cases. Increased level (>5) of fibrin degradation products was seen in 30 (22.2%) cases while at the time of discharge increased level of fibrin degradation products was observed in 25 (18.5%) cases (pvalue 0.007). Out of 135 patients, mortality was observed in two cases and the remaining 133 (98.52%) survived and were discharged.
Conclusion: In conclusion, prothrombin time, activated partial thromboplastin time, and fibrin degradation products can be labeled as early predictors of disease severity and their derangements are associated with clinical outcome in dengue infection.</description><identifier>ISSN: 0030-9648</identifier><identifier>EISSN: 2411-8842</identifier><identifier>DOI: 10.51253/pafmj.v72i1.4255</identifier><language>eng</language><publisher>Rawalpindi: Knowledge Bylanes</publisher><subject>Age ; Blood ; Clinical outcomes ; Dengue ; Dengue fever ; Fibrin ; Hematology ; Infection ; Infections ; Males ; Medical examination ; Mosquitoes ; Patient outcomes ; Patients ; Prothrombin ; Thrombin</subject><ispartof>Pakistan Armed Forces medical journal, 2022-02, Vol.72 (1), p.159-63</ispartof><rights>COPYRIGHT 2022 Knowledge Bylanes</rights><rights>(c)2022 Pakistan Armed Forces Medical Journal</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c255t-ca6d879f20539fcf28a6724ebf723b42198501028c058ecdd3168b6a5cd6c20d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids></links><search><creatorcontrib>Irshad, Zareen</creatorcontrib><creatorcontrib>Jaffar, Nazish</creatorcontrib><creatorcontrib>Zehra, Talat</creatorcontrib><creatorcontrib>Zeeshan, Faiza</creatorcontrib><creatorcontrib>Tashfeen, Sunila</creatorcontrib><creatorcontrib>Sheikh, Asma</creatorcontrib><title>Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients</title><title>Pakistan Armed Forces medical journal</title><description>Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient.
Study Design: Cross-sectional study.
Place and Duration of Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Karachi Pakistan, from Aug 2016 to Feb 2017.
Methodology: A total of 135, serologically proven positive dengue-infected IgM cases, based on enzyme-linked immunesorbent assay, were included in the study. Prothrombin time, activated partial thromboplastin time, and fibrin degradation products levels were measured on STA Compact Max® (STAGO) and SysmexCA-1500. Clinical Outcomes of the patient were noted.
Results: At the time of admission, elevated prothrombin time was observed in 8(5.6%) cases and remained high at the time of discharge (p-value 0.008). Elevated activated partial thromboplastin time was observed in 57 (42.2%) cases at admission whereas, at discharge, it was observed in 56 (41.5%) cases. Increased level (>5) of fibrin degradation products was seen in 30 (22.2%) cases while at the time of discharge increased level of fibrin degradation products was observed in 25 (18.5%) cases (pvalue 0.007). Out of 135 patients, mortality was observed in two cases and the remaining 133 (98.52%) survived and were discharged.
Conclusion: In conclusion, prothrombin time, activated partial thromboplastin time, and fibrin degradation products can be labeled as early predictors of disease severity and their derangements are associated with clinical outcome in dengue infection.</description><subject>Age</subject><subject>Blood</subject><subject>Clinical outcomes</subject><subject>Dengue</subject><subject>Dengue fever</subject><subject>Fibrin</subject><subject>Hematology</subject><subject>Infection</subject><subject>Infections</subject><subject>Males</subject><subject>Medical examination</subject><subject>Mosquitoes</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prothrombin</subject><subject>Thrombin</subject><issn>0030-9648</issn><issn>2411-8842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptUU1LAzEUDKJgqf0B3gKet-Zjk02PpVoVCvVQzzHNJm3KblKT3Yr_3rQVRPC9w4NhZt7AAHCL0Zhhwuj9Xtl2Nz5UxOFxSRi7AANSYlwIUZJLMECIomLCS3ENRintUB5GSYnYALxPUwraqc4FD4OF07UPsVUNnAW16ZszvjKpS9B5-GD8pjdwbg4mwk_XbeGscd7pzF_2nQ6tSUeT1dbA1yw1vks34MqqJpnRzx2Ct_njavZcLJZPL7PpotA5b1doxWtRTSzJySZWWyIUr0hp1rYidF0SPBEMYUSERkwYXdcUc7Hmiumaa4JqOgR3Z999DB99Dix3oY8-v5SEM8aQ4CX-ZW1UY6TzNnRR6dYlLacVwhxRLGhmjf9h5a1N63TwxrqM_xHgs0DHkFI0Vu6ja1X8khjJU0XyVJE8VSSPFdFvmgSD6g</recordid><startdate>20220228</startdate><enddate>20220228</enddate><creator>Irshad, Zareen</creator><creator>Jaffar, Nazish</creator><creator>Zehra, Talat</creator><creator>Zeeshan, Faiza</creator><creator>Tashfeen, Sunila</creator><creator>Sheikh, Asma</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220228</creationdate><title>Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients</title><author>Irshad, Zareen ; Jaffar, Nazish ; Zehra, Talat ; Zeeshan, Faiza ; Tashfeen, Sunila ; Sheikh, Asma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-ca6d879f20539fcf28a6724ebf723b42198501028c058ecdd3168b6a5cd6c20d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Blood</topic><topic>Clinical outcomes</topic><topic>Dengue</topic><topic>Dengue fever</topic><topic>Fibrin</topic><topic>Hematology</topic><topic>Infection</topic><topic>Infections</topic><topic>Males</topic><topic>Medical examination</topic><topic>Mosquitoes</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Prothrombin</topic><topic>Thrombin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irshad, Zareen</creatorcontrib><creatorcontrib>Jaffar, Nazish</creatorcontrib><creatorcontrib>Zehra, Talat</creatorcontrib><creatorcontrib>Zeeshan, Faiza</creatorcontrib><creatorcontrib>Tashfeen, Sunila</creatorcontrib><creatorcontrib>Sheikh, Asma</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pakistan Armed Forces medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irshad, Zareen</au><au>Jaffar, Nazish</au><au>Zehra, Talat</au><au>Zeeshan, Faiza</au><au>Tashfeen, Sunila</au><au>Sheikh, Asma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients</atitle><jtitle>Pakistan Armed Forces medical journal</jtitle><date>2022-02-28</date><risdate>2022</risdate><volume>72</volume><issue>1</issue><spage>159</spage><epage>63</epage><pages>159-63</pages><issn>0030-9648</issn><eissn>2411-8842</eissn><abstract>Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients and its impact on clinical outcomes of the patient.
Study Design: Cross-sectional study.
Place and Duration of Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Karachi Pakistan, from Aug 2016 to Feb 2017.
Methodology: A total of 135, serologically proven positive dengue-infected IgM cases, based on enzyme-linked immunesorbent assay, were included in the study. Prothrombin time, activated partial thromboplastin time, and fibrin degradation products levels were measured on STA Compact Max® (STAGO) and SysmexCA-1500. Clinical Outcomes of the patient were noted.
Results: At the time of admission, elevated prothrombin time was observed in 8(5.6%) cases and remained high at the time of discharge (p-value 0.008). Elevated activated partial thromboplastin time was observed in 57 (42.2%) cases at admission whereas, at discharge, it was observed in 56 (41.5%) cases. Increased level (>5) of fibrin degradation products was seen in 30 (22.2%) cases while at the time of discharge increased level of fibrin degradation products was observed in 25 (18.5%) cases (pvalue 0.007). Out of 135 patients, mortality was observed in two cases and the remaining 133 (98.52%) survived and were discharged.
Conclusion: In conclusion, prothrombin time, activated partial thromboplastin time, and fibrin degradation products can be labeled as early predictors of disease severity and their derangements are associated with clinical outcome in dengue infection.</abstract><cop>Rawalpindi</cop><pub>Knowledge Bylanes</pub><doi>10.51253/pafmj.v72i1.4255</doi><tpages>-95</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Blood Clinical outcomes Dengue Dengue fever Fibrin Hematology Infection Infections Males Medical examination Mosquitoes Patient outcomes Patients Prothrombin Thrombin |
| title | Association of Abnormal Coagulation Tests in Dengue Fever with Clinical Outcomes of The Patients |
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