Frequency And Significance of Electrocardiographic Changes in Beta Thalassemia Major Patients
Objective: To find out the electrocardiographic changes among beta thalassemia major patients as the marker of cardiac complications at later stages of life. Study Design: Prospective observational study. Place and Duration of Study: Department of Pediatrics and Neonatology, Pak Emirates Military Ho...
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| Veröffentlicht in: | Pakistan Armed Forces medical journal 2022-02, Vol.72 (1), p.136-40 |
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| container_title | Pakistan Armed Forces medical journal |
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| creator | Hamid, Naila Shafique, Muhammad Faisal Zaman, Qamar -uz Niaz, Hafsa |
| description | Objective: To find out the electrocardiographic changes among beta thalassemia major patients as the marker of cardiac complications at later stages of life.
Study Design: Prospective observational study.
Place and Duration of Study: Department of Pediatrics and Neonatology, Pak Emirates Military Hospital Rawalpindi from Jul 2018 to Dec 2018.
Methodology: One hundred and thirty patients of age 5-20 years with beta thalassemia major were included in the study. Patients were attending the thalassemia centre regularly.
Results: Out of total 130 patients, 70 (53.84%) were males and 60 (46.15%) were females. Out of 81 (56.92%) patients showed at least one electrocardiographic change while 49 (37.69%) patients showed normal electrocardiography. Remarkable electrocardiographic changes were sinus tachycardia, arrhythmias, T-wave inversions, long QTc interval and sinus bradycardia. There was statistically significant association in the increased serum ferritin levels, electrocardiographic changes, number of blood transfusions and occurrence of ECG changes (p |
| doi_str_mv | 10.51253/pafmj.v72i1.3725 |
| format | Article |
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Study Design: Prospective observational study.
Place and Duration of Study: Department of Pediatrics and Neonatology, Pak Emirates Military Hospital Rawalpindi from Jul 2018 to Dec 2018.
Methodology: One hundred and thirty patients of age 5-20 years with beta thalassemia major were included in the study. Patients were attending the thalassemia centre regularly.
Results: Out of total 130 patients, 70 (53.84%) were males and 60 (46.15%) were females. Out of 81 (56.92%) patients showed at least one electrocardiographic change while 49 (37.69%) patients showed normal electrocardiography. Remarkable electrocardiographic changes were sinus tachycardia, arrhythmias, T-wave inversions, long QTc interval and sinus bradycardia. There was statistically significant association in the increased serum ferritin levels, electrocardiographic changes, number of blood transfusions and occurrence of ECG changes (p<0.05).
Conclusion: Regular electrocardiographic monitoring has significant role in cardiac evaluation of beta thalassemia major patients as an indicator of evolving cardiac complications that can arise from iron overload secondary to multiple blood transfusions.</description><identifier>ISSN: 0030-9648</identifier><identifier>EISSN: 2411-8842</identifier><identifier>DOI: 10.51253/pafmj.v72i1.3725</identifier><language>eng</language><publisher>Rawalpindi: Knowledge Bylanes</publisher><subject>Age ; Blood diseases ; Blood transfusion ; Blood transfusions ; Cardiac arrhythmia ; Cardiomyopathy ; Cardiovascular diseases ; Care and treatment ; Electrocardiogram ; Electrocardiography ; Ferritin ; Heart failure ; Heart rate ; Males ; Metronidazole ; Mortality ; Neonatology ; Patients ; Sinuses ; Thalassemia</subject><ispartof>Pakistan Armed Forces medical journal, 2022-02, Vol.72 (1), p.136-40</ispartof><rights>COPYRIGHT 2022 Knowledge Bylanes</rights><rights>(c)2022 Pakistan Armed Forces Medical Journal</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Hamid, Naila</creatorcontrib><creatorcontrib>Shafique, Muhammad Faisal</creatorcontrib><creatorcontrib>Zaman, Qamar -uz</creatorcontrib><creatorcontrib>Niaz, Hafsa</creatorcontrib><title>Frequency And Significance of Electrocardiographic Changes in Beta Thalassemia Major Patients</title><title>Pakistan Armed Forces medical journal</title><description>Objective: To find out the electrocardiographic changes among beta thalassemia major patients as the marker of cardiac complications at later stages of life.
Study Design: Prospective observational study.
Place and Duration of Study: Department of Pediatrics and Neonatology, Pak Emirates Military Hospital Rawalpindi from Jul 2018 to Dec 2018.
Methodology: One hundred and thirty patients of age 5-20 years with beta thalassemia major were included in the study. Patients were attending the thalassemia centre regularly.
Results: Out of total 130 patients, 70 (53.84%) were males and 60 (46.15%) were females. Out of 81 (56.92%) patients showed at least one electrocardiographic change while 49 (37.69%) patients showed normal electrocardiography. Remarkable electrocardiographic changes were sinus tachycardia, arrhythmias, T-wave inversions, long QTc interval and sinus bradycardia. There was statistically significant association in the increased serum ferritin levels, electrocardiographic changes, number of blood transfusions and occurrence of ECG changes (p<0.05).
Conclusion: Regular electrocardiographic monitoring has significant role in cardiac evaluation of beta thalassemia major patients as an indicator of evolving cardiac complications that can arise from iron overload secondary to multiple blood transfusions.</description><subject>Age</subject><subject>Blood diseases</subject><subject>Blood transfusion</subject><subject>Blood transfusions</subject><subject>Cardiac arrhythmia</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Electrocardiogram</subject><subject>Electrocardiography</subject><subject>Ferritin</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Males</subject><subject>Metronidazole</subject><subject>Mortality</subject><subject>Neonatology</subject><subject>Patients</subject><subject>Sinuses</subject><subject>Thalassemia</subject><issn>0030-9648</issn><issn>2411-8842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkVtLAzEQhYMoWKo_wLeAz1tz3ctjLd6goqA-SpjNTtqUNqnJKvjvXVtBBGceBoZzZjh8hJxxNtFcaHmxBbdZTT4q4flEVkIfkJFQnBd1rcQhGTEmWdGUqj4mpzmv2FBaCsX0iLxeJ3x7x2A_6TR09MkvgnfeQrBIo6NXa7R9ihZS5-MiwXbpLZ0tISwwUx_oJfZAn5ewhpxx44Hewyom-gi9x9DnE3LkYJ3x9GeOycv11fPstpg_3NzNpvPCClb1hRQolGoRVFu6BmXViRoUk2XXAqsUF13TMuY41oq30tXaQtk11iE2bakH4Zic7-9uUxzS5N6s4nsKw0sjSq01qxomflULWKPxwcU-gd34bM20Yrxkklf1oJr8oxq6GwLaGND5Yf_HwPcGm2LOCZ3ZJr-B9Gk4Mzs-ZsfH7PiYbz7yC5_wg7E</recordid><startdate>20220228</startdate><enddate>20220228</enddate><creator>Hamid, Naila</creator><creator>Shafique, Muhammad Faisal</creator><creator>Zaman, Qamar -uz</creator><creator>Niaz, Hafsa</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220228</creationdate><title>Frequency And Significance of Electrocardiographic Changes in Beta Thalassemia Major Patients</title><author>Hamid, Naila ; Shafique, Muhammad Faisal ; Zaman, Qamar -uz ; Niaz, Hafsa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c207t-32e244bea4b6f9e37d28a4036dba07412d9b00f1e841b3f85ca6d9cfee9b65403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Blood diseases</topic><topic>Blood transfusion</topic><topic>Blood transfusions</topic><topic>Cardiac arrhythmia</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Electrocardiogram</topic><topic>Electrocardiography</topic><topic>Ferritin</topic><topic>Heart failure</topic><topic>Heart rate</topic><topic>Males</topic><topic>Metronidazole</topic><topic>Mortality</topic><topic>Neonatology</topic><topic>Patients</topic><topic>Sinuses</topic><topic>Thalassemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamid, Naila</creatorcontrib><creatorcontrib>Shafique, Muhammad Faisal</creatorcontrib><creatorcontrib>Zaman, Qamar -uz</creatorcontrib><creatorcontrib>Niaz, Hafsa</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pakistan Armed Forces medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamid, Naila</au><au>Shafique, Muhammad Faisal</au><au>Zaman, Qamar -uz</au><au>Niaz, Hafsa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency And Significance of Electrocardiographic Changes in Beta Thalassemia Major Patients</atitle><jtitle>Pakistan Armed Forces medical journal</jtitle><date>2022-02-28</date><risdate>2022</risdate><volume>72</volume><issue>1</issue><spage>136</spage><epage>40</epage><pages>136-40</pages><issn>0030-9648</issn><eissn>2411-8842</eissn><abstract>Objective: To find out the electrocardiographic changes among beta thalassemia major patients as the marker of cardiac complications at later stages of life.
Study Design: Prospective observational study.
Place and Duration of Study: Department of Pediatrics and Neonatology, Pak Emirates Military Hospital Rawalpindi from Jul 2018 to Dec 2018.
Methodology: One hundred and thirty patients of age 5-20 years with beta thalassemia major were included in the study. Patients were attending the thalassemia centre regularly.
Results: Out of total 130 patients, 70 (53.84%) were males and 60 (46.15%) were females. Out of 81 (56.92%) patients showed at least one electrocardiographic change while 49 (37.69%) patients showed normal electrocardiography. Remarkable electrocardiographic changes were sinus tachycardia, arrhythmias, T-wave inversions, long QTc interval and sinus bradycardia. There was statistically significant association in the increased serum ferritin levels, electrocardiographic changes, number of blood transfusions and occurrence of ECG changes (p<0.05).
Conclusion: Regular electrocardiographic monitoring has significant role in cardiac evaluation of beta thalassemia major patients as an indicator of evolving cardiac complications that can arise from iron overload secondary to multiple blood transfusions.</abstract><cop>Rawalpindi</cop><pub>Knowledge Bylanes</pub><doi>10.51253/pafmj.v72i1.3725</doi><tpages>-95</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Blood diseases Blood transfusion Blood transfusions Cardiac arrhythmia Cardiomyopathy Cardiovascular diseases Care and treatment Electrocardiogram Electrocardiography Ferritin Heart failure Heart rate Males Metronidazole Mortality Neonatology Patients Sinuses Thalassemia |
| title | Frequency And Significance of Electrocardiographic Changes in Beta Thalassemia Major Patients |
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