Overexpression of Twist1 in vascular endothelial cells promotes pathological retinal angiogenesis in mice

Retinal angiogenesis is a critical process for normal retinal function. However, uncontrolled angiogenesis can lead to pathological neovascularization (NV), which is closely related to most irreversible blindness-causing retinal diseases. Understanding the molecular basis behind pathological NV is i...

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Veröffentlicht in:	Dōngwùxué yánjiū 2022-01, Vol.43 (1), p.64-74
Hauptverfasser:	Zhang, Lin, Zhang, Shan-Shan, Wang, Kai-Fang, Li, Yi-Hui, Xu, Hui-Juan, Sun, Kuan-Xiang, Ma, Shi, Leng, Hong-Mei, Chen, Si-Zhu, Jia, Wen-Jing, Zhu, Xian-Jun, Li, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies Blindness Cell growth Cell proliferation Diabetic retinopathy Diseases Endothelial Cells Gene expression Genes Mice Mice, Transgenic Neovascularization, Pathologic - genetics Neovascularization, Pathologic - veterinary Permeability Physiology Polarity Polymerase chain reaction Proliferation Retina Retinal Neovascularization - genetics Retinal Neovascularization - veterinary Rodents Signal transduction Therapeutic targets Transcription Transcription factors Transgenic mice Twist-Related Protein 1 - genetics Vascular endothelial growth factor Vascularization Wnt protein
Online-Zugang:	Volltext
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