2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study

Epidermal Growth Factor Receptor (EGFR), and Human EGFR-related Receptor 2 (HER2) are validated targets for anticancer drugs which provide synergistic effects when targeted simultaneously. In the previous in silico study, ZINC21942954 which is a 2-substituted 4-aminoquinazoline derivative containing...

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Veröffentlicht in:Medicinal chemistry research 2022-05, Vol.31 (5), p.762-771
Hauptverfasser: Sangande, Frangky, Julianti, Elin, Tjahjono, Daryono Hadi
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Sprache:eng
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