Multigram-scale synthesis of GSK 2,256,294, an inhibitor of soluble epoxide hydrolase in clinical evaluation

This paper described the development of an improved, practical and efficient protocol method for the multigram-scale synthesis of GSK 2,256,294, an orally bioavailable potent and selective inhibitor of sEH. The key to this optimization was the design and development of a novel synthetic strategy, wh...

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Veröffentlicht in:	Chemical papers 2022-05, Vol.76 (5), p.2883-2891
Hauptverfasser:	Duan, Meibo, Fu, Siyu, Han, Yu, Tian, Ye, Jiang, Jia, Xing, Yongpeng, Hou, Yunlei, Zhao, Yanfang
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzonitrile Bioavailability Biochemistry Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Design optimization Industrial Chemistry/Chemical Engineering Inhibitors Materials Science Medicinal Chemistry Original Paper Synthesis
Online-Zugang:	Volltext
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