Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region
Background Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region. Methods We surveyed retrospective data f...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2022-05, Vol.148 (5), p.1153-1158 |
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| creator | Uramoto, Hidetaka Takiguchi, Tomoya Koizumi, Tomonobu Tanimoto, Azusa Hayashi, Ryuji Nakazawa, Yozo Ito, Ken-ichi Nakada, Mitsutoshi Hirono, Yasuo Nishino, Yoshikazu Yano, Seiji |
| description | Background
Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region.
Methods
We surveyed retrospective data from 152,921 cancer patients in 22 principal hospitals.
Results
A total of 166 MPM cases were newly diagnosed. These patients consisted of 136 men and 30 women, with a median age of 69 years. We estimated the incidence rate for MPM to be 0.55 cases per 100,000 person-years in this study. The ratio per 100,000 population-years was 0.39 in Fukui, 0.60 in Ishikawa, 1.02 in Toyama and 0.35 in Nagano. Forty-five patients were discovered when diagnosed incidentally in patients under observations for other diseases. Forty-six cases were diagnosed as localized disease, while 13 had accompanying regional lymph node metastasis. Furthermore, 44 cases showed infiltration into adjacent organs. A histo-cytological diagnosis was made in 164 cases (98.8%). A surgical approach, chemotherapy, and radiotherapy were performed for 33, 88, and 6 patients, respectively, while 44 patients (26.5%) received best supportive care. Multimodality therapy was conducted in just 3.0% of the MPM patients
Conclusion
MPM has a tragically rapid progression if discovered under observations for other diseases. Workers in health-related fields should be on high alert for aggressive MPM. Better evaluation and multi-disciplinary approaches to MPM in these regions are needed to optimize multimodality therapy. |
| doi_str_mv | 10.1007/s00432-021-03699-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2651907276</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2651907276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-5e6b1a8bbb38c0ca91fcf9b28a9bed53d00d2284796b49f503efa473cc345c0b3</originalsourceid><addsrcrecordid>eNp9kElPwzAQhS0EoqXwBzigSJwDYzvOckQVUKQiLnBDsuzEaV2y4QWp_fW4hOXGafRm3rzRfAidY7jCANm1BUgoiYHgGGhaFPHuAE3xvoUpZYdoCjjDMSM4naATazcQNMvIMZrQBOcMJ2SKXh9943SsO-u08073nWgi682H2kZ9HbWi0atOdC4aGuVNmLXK9m6tGt23IhqE06pzNtJdFJrRon_zdh2EUasQdYqOatFYdfZdZ-jl7vZ5voiXT_cP85tlXNIMXMxUKrHIpZQ0L6EUBa7LupAkF4VUFaMVQEVInmRFKpOiZkBVLZKMliVNWAmSztDlmDuY_t0r6_im9yZ8YjlJGS4gI1kaXGR0laa31qiaD0a3wmw5Br4HykegPADlX0D5LixdfEd72arqd-WHYDDQ0WDDqFsp83f7n9hP9RyDfQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2651907276</pqid></control><display><type>article</type><title>Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Uramoto, Hidetaka ; Takiguchi, Tomoya ; Koizumi, Tomonobu ; Tanimoto, Azusa ; Hayashi, Ryuji ; Nakazawa, Yozo ; Ito, Ken-ichi ; Nakada, Mitsutoshi ; Hirono, Yasuo ; Nishino, Yoshikazu ; Yano, Seiji</creator><creatorcontrib>Uramoto, Hidetaka ; Takiguchi, Tomoya ; Koizumi, Tomonobu ; Tanimoto, Azusa ; Hayashi, Ryuji ; Nakazawa, Yozo ; Ito, Ken-ichi ; Nakada, Mitsutoshi ; Hirono, Yasuo ; Nishino, Yoshikazu ; Yano, Seiji</creatorcontrib><description>Background
Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region.
Methods
We surveyed retrospective data from 152,921 cancer patients in 22 principal hospitals.
Results
A total of 166 MPM cases were newly diagnosed. These patients consisted of 136 men and 30 women, with a median age of 69 years. We estimated the incidence rate for MPM to be 0.55 cases per 100,000 person-years in this study. The ratio per 100,000 population-years was 0.39 in Fukui, 0.60 in Ishikawa, 1.02 in Toyama and 0.35 in Nagano. Forty-five patients were discovered when diagnosed incidentally in patients under observations for other diseases. Forty-six cases were diagnosed as localized disease, while 13 had accompanying regional lymph node metastasis. Furthermore, 44 cases showed infiltration into adjacent organs. A histo-cytological diagnosis was made in 164 cases (98.8%). A surgical approach, chemotherapy, and radiotherapy were performed for 33, 88, and 6 patients, respectively, while 44 patients (26.5%) received best supportive care. Multimodality therapy was conducted in just 3.0% of the MPM patients
Conclusion
MPM has a tragically rapid progression if discovered under observations for other diseases. Workers in health-related fields should be on high alert for aggressive MPM. Better evaluation and multi-disciplinary approaches to MPM in these regions are needed to optimize multimodality therapy.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-021-03699-z</identifier><identifier>PMID: 34185142</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Cancer Research ; Chemotherapy ; Diagnosis ; Epidemiology ; Female ; Hematology ; Humans ; Incidence ; Internal Medicine ; Lung Neoplasms - diagnosis ; Lung Neoplasms - epidemiology ; Lung Neoplasms - therapy ; Lymph nodes ; Male ; Medicine ; Medicine & Public Health ; Mesothelioma ; Mesothelioma - epidemiology ; Mesothelioma - therapy ; Mesothelioma, Malignant ; Metastases ; Oncology ; Original Article – Clinical Oncology ; Patients ; Pleural Neoplasms - epidemiology ; Pleural Neoplasms - therapy ; Radiation therapy ; Retrospective Studies</subject><ispartof>Journal of cancer research and clinical oncology, 2022-05, Vol.148 (5), p.1153-1158</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-5e6b1a8bbb38c0ca91fcf9b28a9bed53d00d2284796b49f503efa473cc345c0b3</cites><orcidid>0000-0003-4451-4225</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-021-03699-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-021-03699-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34185142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uramoto, Hidetaka</creatorcontrib><creatorcontrib>Takiguchi, Tomoya</creatorcontrib><creatorcontrib>Koizumi, Tomonobu</creatorcontrib><creatorcontrib>Tanimoto, Azusa</creatorcontrib><creatorcontrib>Hayashi, Ryuji</creatorcontrib><creatorcontrib>Nakazawa, Yozo</creatorcontrib><creatorcontrib>Ito, Ken-ichi</creatorcontrib><creatorcontrib>Nakada, Mitsutoshi</creatorcontrib><creatorcontrib>Hirono, Yasuo</creatorcontrib><creatorcontrib>Nishino, Yoshikazu</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><title>Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Background
Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region.
Methods
We surveyed retrospective data from 152,921 cancer patients in 22 principal hospitals.
Results
A total of 166 MPM cases were newly diagnosed. These patients consisted of 136 men and 30 women, with a median age of 69 years. We estimated the incidence rate for MPM to be 0.55 cases per 100,000 person-years in this study. The ratio per 100,000 population-years was 0.39 in Fukui, 0.60 in Ishikawa, 1.02 in Toyama and 0.35 in Nagano. Forty-five patients were discovered when diagnosed incidentally in patients under observations for other diseases. Forty-six cases were diagnosed as localized disease, while 13 had accompanying regional lymph node metastasis. Furthermore, 44 cases showed infiltration into adjacent organs. A histo-cytological diagnosis was made in 164 cases (98.8%). A surgical approach, chemotherapy, and radiotherapy were performed for 33, 88, and 6 patients, respectively, while 44 patients (26.5%) received best supportive care. Multimodality therapy was conducted in just 3.0% of the MPM patients
Conclusion
MPM has a tragically rapid progression if discovered under observations for other diseases. Workers in health-related fields should be on high alert for aggressive MPM. Better evaluation and multi-disciplinary approaches to MPM in these regions are needed to optimize multimodality therapy.</description><subject>Aged</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - therapy</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesothelioma</subject><subject>Mesothelioma - epidemiology</subject><subject>Mesothelioma - therapy</subject><subject>Mesothelioma, Malignant</subject><subject>Metastases</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Patients</subject><subject>Pleural Neoplasms - epidemiology</subject><subject>Pleural Neoplasms - therapy</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kElPwzAQhS0EoqXwBzigSJwDYzvOckQVUKQiLnBDsuzEaV2y4QWp_fW4hOXGafRm3rzRfAidY7jCANm1BUgoiYHgGGhaFPHuAE3xvoUpZYdoCjjDMSM4naATazcQNMvIMZrQBOcMJ2SKXh9943SsO-u08073nWgi682H2kZ9HbWi0atOdC4aGuVNmLXK9m6tGt23IhqE06pzNtJdFJrRon_zdh2EUasQdYqOatFYdfZdZ-jl7vZ5voiXT_cP85tlXNIMXMxUKrHIpZQ0L6EUBa7LupAkF4VUFaMVQEVInmRFKpOiZkBVLZKMliVNWAmSztDlmDuY_t0r6_im9yZ8YjlJGS4gI1kaXGR0laa31qiaD0a3wmw5Br4HykegPADlX0D5LixdfEd72arqd-WHYDDQ0WDDqFsp83f7n9hP9RyDfQ</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Uramoto, Hidetaka</creator><creator>Takiguchi, Tomoya</creator><creator>Koizumi, Tomonobu</creator><creator>Tanimoto, Azusa</creator><creator>Hayashi, Ryuji</creator><creator>Nakazawa, Yozo</creator><creator>Ito, Ken-ichi</creator><creator>Nakada, Mitsutoshi</creator><creator>Hirono, Yasuo</creator><creator>Nishino, Yoshikazu</creator><creator>Yano, Seiji</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0003-4451-4225</orcidid></search><sort><creationdate>20220501</creationdate><title>Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region</title><author>Uramoto, Hidetaka ; Takiguchi, Tomoya ; Koizumi, Tomonobu ; Tanimoto, Azusa ; Hayashi, Ryuji ; Nakazawa, Yozo ; Ito, Ken-ichi ; Nakada, Mitsutoshi ; Hirono, Yasuo ; Nishino, Yoshikazu ; Yano, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-5e6b1a8bbb38c0ca91fcf9b28a9bed53d00d2284796b49f503efa473cc345c0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - therapy</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesothelioma</topic><topic>Mesothelioma - epidemiology</topic><topic>Mesothelioma - therapy</topic><topic>Mesothelioma, Malignant</topic><topic>Metastases</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Patients</topic><topic>Pleural Neoplasms - epidemiology</topic><topic>Pleural Neoplasms - therapy</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uramoto, Hidetaka</creatorcontrib><creatorcontrib>Takiguchi, Tomoya</creatorcontrib><creatorcontrib>Koizumi, Tomonobu</creatorcontrib><creatorcontrib>Tanimoto, Azusa</creatorcontrib><creatorcontrib>Hayashi, Ryuji</creatorcontrib><creatorcontrib>Nakazawa, Yozo</creatorcontrib><creatorcontrib>Ito, Ken-ichi</creatorcontrib><creatorcontrib>Nakada, Mitsutoshi</creatorcontrib><creatorcontrib>Hirono, Yasuo</creatorcontrib><creatorcontrib>Nishino, Yoshikazu</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uramoto, Hidetaka</au><au>Takiguchi, Tomoya</au><au>Koizumi, Tomonobu</au><au>Tanimoto, Azusa</au><au>Hayashi, Ryuji</au><au>Nakazawa, Yozo</au><au>Ito, Ken-ichi</au><au>Nakada, Mitsutoshi</au><au>Hirono, Yasuo</au><au>Nishino, Yoshikazu</au><au>Yano, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>148</volume><issue>5</issue><spage>1153</spage><epage>1158</epage><pages>1153-1158</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Background
Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region.
Methods
We surveyed retrospective data from 152,921 cancer patients in 22 principal hospitals.
Results
A total of 166 MPM cases were newly diagnosed. These patients consisted of 136 men and 30 women, with a median age of 69 years. We estimated the incidence rate for MPM to be 0.55 cases per 100,000 person-years in this study. The ratio per 100,000 population-years was 0.39 in Fukui, 0.60 in Ishikawa, 1.02 in Toyama and 0.35 in Nagano. Forty-five patients were discovered when diagnosed incidentally in patients under observations for other diseases. Forty-six cases were diagnosed as localized disease, while 13 had accompanying regional lymph node metastasis. Furthermore, 44 cases showed infiltration into adjacent organs. A histo-cytological diagnosis was made in 164 cases (98.8%). A surgical approach, chemotherapy, and radiotherapy were performed for 33, 88, and 6 patients, respectively, while 44 patients (26.5%) received best supportive care. Multimodality therapy was conducted in just 3.0% of the MPM patients
Conclusion
MPM has a tragically rapid progression if discovered under observations for other diseases. Workers in health-related fields should be on high alert for aggressive MPM. Better evaluation and multi-disciplinary approaches to MPM in these regions are needed to optimize multimodality therapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34185142</pmid><doi>10.1007/s00432-021-03699-z</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4451-4225</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Cancer Research Chemotherapy Diagnosis Epidemiology Female Hematology Humans Incidence Internal Medicine Lung Neoplasms - diagnosis Lung Neoplasms - epidemiology Lung Neoplasms - therapy Lymph nodes Male Medicine Medicine & Public Health Mesothelioma Mesothelioma - epidemiology Mesothelioma - therapy Mesothelioma, Malignant Metastases Oncology Original Article – Clinical Oncology Patients Pleural Neoplasms - epidemiology Pleural Neoplasms - therapy Radiation therapy Retrospective Studies |
| title | Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region |
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