Controllable fabrication of multi‐modal porous PLGA scaffolds with different sizes of SPIONs using supercritical CO2 foaming
Multi‐modal porous scaffolds can promote bone regeneration. In the present study, they were successfully fabricated from poly (lactic‐co‐glycolic acid) (PLGA)/superparamagnetic iron oxide nanoparticles (SPIONs) by supercritical CO2 foaming, where SPIONs was employed as heterogeneous nucleation agent...
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| Veröffentlicht in: | Journal of applied polymer science 2022-06, Vol.139 (23), p.n/a |
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| creator | Wang, Jinjing Zhang, Yi Sun, Jianfei Jiao, Zhen |
| description | Multi‐modal porous scaffolds can promote bone regeneration. In the present study, they were successfully fabricated from poly (lactic‐co‐glycolic acid) (PLGA)/superparamagnetic iron oxide nanoparticles (SPIONs) by supercritical CO2 foaming, where SPIONs was employed as heterogeneous nucleation agent. The effects of SPION size on pore nucleation in PLGA/SPIONs nanocomposites were investigated. It was found that the addition of smaller SPIONs size caused the reduction of pore size. Multi‐modal porous scaffolds could be available by controlling the SPIONs content, soaking temperature, pressure, and depressurization rate. The porosity of the PLGA/SPIONs scaffolds ranged from (58.68 ± 0.62)% to (94.97 ± 0.14)% could be obtained via adjusting the supercritical CO2 foaming conditions. Moreover, it was found that the compressive modulus and porosity of the scaffolds were strongly associated with the porous structure. This study provided a new green preparation method for magnetic scaffolds to realize the controllable adjustment of the multi‐mode porous scaffolds.
Different sizes of superparamagnetic iron oxide nanoparticles (SPIONs) can be used as the nucleating agents to control the pore structure and effectively improve the porosity of scaffolds during the supercritical CO2 foaming process. SPIONs‐PLGA scaffolds with multi‐modal pores were successfully fabricated via adjusting operation conditions of supercritical CO2 foaming process. |
| doi_str_mv | 10.1002/app.52287 |
| format | Article |
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Different sizes of superparamagnetic iron oxide nanoparticles (SPIONs) can be used as the nucleating agents to control the pore structure and effectively improve the porosity of scaffolds during the supercritical CO2 foaming process. SPIONs‐PLGA scaffolds with multi‐modal pores were successfully fabricated via adjusting operation conditions of supercritical CO2 foaming process.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.52287</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>bioengineering ; Carbon dioxide ; composites ; Controllability ; Foaming ; Glycolic acid ; Iron oxides ; Materials science ; Modulus of elasticity ; Nanocomposites ; Nanoparticles ; Nucleation ; Polymers ; Pore size ; Porosity ; porous materials ; Pressure reduction ; Regeneration (physiology) ; Scaffolds</subject><ispartof>Journal of applied polymer science, 2022-06, Vol.139 (23), p.n/a</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5383-5077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.52287$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.52287$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Wang, Jinjing</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Sun, Jianfei</creatorcontrib><creatorcontrib>Jiao, Zhen</creatorcontrib><title>Controllable fabrication of multi‐modal porous PLGA scaffolds with different sizes of SPIONs using supercritical CO2 foaming</title><title>Journal of applied polymer science</title><description>Multi‐modal porous scaffolds can promote bone regeneration. In the present study, they were successfully fabricated from poly (lactic‐co‐glycolic acid) (PLGA)/superparamagnetic iron oxide nanoparticles (SPIONs) by supercritical CO2 foaming, where SPIONs was employed as heterogeneous nucleation agent. The effects of SPION size on pore nucleation in PLGA/SPIONs nanocomposites were investigated. It was found that the addition of smaller SPIONs size caused the reduction of pore size. Multi‐modal porous scaffolds could be available by controlling the SPIONs content, soaking temperature, pressure, and depressurization rate. The porosity of the PLGA/SPIONs scaffolds ranged from (58.68 ± 0.62)% to (94.97 ± 0.14)% could be obtained via adjusting the supercritical CO2 foaming conditions. Moreover, it was found that the compressive modulus and porosity of the scaffolds were strongly associated with the porous structure. This study provided a new green preparation method for magnetic scaffolds to realize the controllable adjustment of the multi‐mode porous scaffolds.
Different sizes of superparamagnetic iron oxide nanoparticles (SPIONs) can be used as the nucleating agents to control the pore structure and effectively improve the porosity of scaffolds during the supercritical CO2 foaming process. SPIONs‐PLGA scaffolds with multi‐modal pores were successfully fabricated via adjusting operation conditions of supercritical CO2 foaming process.</description><subject>bioengineering</subject><subject>Carbon dioxide</subject><subject>composites</subject><subject>Controllability</subject><subject>Foaming</subject><subject>Glycolic acid</subject><subject>Iron oxides</subject><subject>Materials science</subject><subject>Modulus of elasticity</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Nucleation</subject><subject>Polymers</subject><subject>Pore size</subject><subject>Porosity</subject><subject>porous materials</subject><subject>Pressure reduction</subject><subject>Regeneration (physiology)</subject><subject>Scaffolds</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNotkN9KwzAUxoMoOKcXvkHA627503bt5Rg6B8MV1OuQpIlmpE1NWsa8EB_BZ_RJzDavzoHvO9_H-QFwi9EEI0SmvOsmGSHF7AyMMCpnSZqT4hyMooaToiyzS3AVwhYhjDOUj8DXwrW9d9ZyYRXUXHgjeW9cC52GzWB78_v907iaW9g574YAq_VyDoPkWjtbB7gz_TusjdbKq7aHwXyqcLh9rlabpwCHYNo3GIZOeelNH8MtXGwI1I43UbkGF5rboG7-5xi8Pty_LB6T9Wa5WszXSUcInSWyVBpLUVCBsjpNidIprVNEUYkkEVmaC06wSAWXvC605gWXWa1KgRSNj5cpHYO7U27n3cegQs-2bvBtrGQkzxBBNPZE1_Tk2hmr9qzzpuF-zzBiB7YssmVHtmxeVceF_gGqnHEs</recordid><startdate>20220615</startdate><enddate>20220615</enddate><creator>Wang, Jinjing</creator><creator>Zhang, Yi</creator><creator>Sun, Jianfei</creator><creator>Jiao, Zhen</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-5383-5077</orcidid></search><sort><creationdate>20220615</creationdate><title>Controllable fabrication of multi‐modal porous PLGA scaffolds with different sizes of SPIONs using supercritical CO2 foaming</title><author>Wang, Jinjing ; Zhang, Yi ; Sun, Jianfei ; Jiao, Zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2237-c9ef1cb83b05d442ef43d403090c2b546ba21b4bacad8ffa8ac5de9b0e3002943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>bioengineering</topic><topic>Carbon dioxide</topic><topic>composites</topic><topic>Controllability</topic><topic>Foaming</topic><topic>Glycolic acid</topic><topic>Iron oxides</topic><topic>Materials science</topic><topic>Modulus of elasticity</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>Nucleation</topic><topic>Polymers</topic><topic>Pore size</topic><topic>Porosity</topic><topic>porous materials</topic><topic>Pressure reduction</topic><topic>Regeneration (physiology)</topic><topic>Scaffolds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jinjing</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Sun, Jianfei</creatorcontrib><creatorcontrib>Jiao, Zhen</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jinjing</au><au>Zhang, Yi</au><au>Sun, Jianfei</au><au>Jiao, Zhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controllable fabrication of multi‐modal porous PLGA scaffolds with different sizes of SPIONs using supercritical CO2 foaming</atitle><jtitle>Journal of applied polymer science</jtitle><date>2022-06-15</date><risdate>2022</risdate><volume>139</volume><issue>23</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>Multi‐modal porous scaffolds can promote bone regeneration. In the present study, they were successfully fabricated from poly (lactic‐co‐glycolic acid) (PLGA)/superparamagnetic iron oxide nanoparticles (SPIONs) by supercritical CO2 foaming, where SPIONs was employed as heterogeneous nucleation agent. The effects of SPION size on pore nucleation in PLGA/SPIONs nanocomposites were investigated. It was found that the addition of smaller SPIONs size caused the reduction of pore size. Multi‐modal porous scaffolds could be available by controlling the SPIONs content, soaking temperature, pressure, and depressurization rate. The porosity of the PLGA/SPIONs scaffolds ranged from (58.68 ± 0.62)% to (94.97 ± 0.14)% could be obtained via adjusting the supercritical CO2 foaming conditions. Moreover, it was found that the compressive modulus and porosity of the scaffolds were strongly associated with the porous structure. This study provided a new green preparation method for magnetic scaffolds to realize the controllable adjustment of the multi‐mode porous scaffolds.
Different sizes of superparamagnetic iron oxide nanoparticles (SPIONs) can be used as the nucleating agents to control the pore structure and effectively improve the porosity of scaffolds during the supercritical CO2 foaming process. SPIONs‐PLGA scaffolds with multi‐modal pores were successfully fabricated via adjusting operation conditions of supercritical CO2 foaming process.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.52287</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5383-5077</orcidid></addata></record> |
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| subjects | bioengineering Carbon dioxide composites Controllability Foaming Glycolic acid Iron oxides Materials science Modulus of elasticity Nanocomposites Nanoparticles Nucleation Polymers Pore size Porosity porous materials Pressure reduction Regeneration (physiology) Scaffolds |
| title | Controllable fabrication of multi‐modal porous PLGA scaffolds with different sizes of SPIONs using supercritical CO2 foaming |
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