Design, synthesis, and computational explorations of novel 2‐thiohydantoin nucleosides with cytotoxic activities

A novel series of S‐alkylated, N‐alkylated, and N‐glycosylated 2‐thiohydantoin derivatives were synthesized via the reaction of (E)‐5‐(arylidene)‐1‐phenyl‐2‐thiohydantoins 5a–d with alkyl halides/glycosyl bromides under aqueous, anhydrous alkaline/glycosylation conditions, respectively. The structur...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2022-04, Vol.59 (4), p.664-685
Hauptverfasser:	Khodair, Ahmed I., Bakare, Safyah B., Awad, Mohamed K., Al‐Issa, Siham A., Nafie, Mohamed S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Bromides Chemical synthesis Crystallization Cytotoxicity Halides Kinases Mathematical analysis Quantum chemistry
Online-Zugang:	Volltext
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